PMID: 9648521Jul 2, 1998Paper

Controlled insulin release from chitosan microparticles

Archiv der Pharmazie
F BugamelliV Zecchi

Abstract

This study deals with the production of chitosan microparticles containing insulin by interfacial crosslinkage of chitosan solubilized in the aqueous phase of a water/oil dispersion in the presence of ascorbyl palmitate. The use of ascorbyl palmitate as interfacial crosslinker is based on its amphiphilic properties allowing its disposition at the water/oil interface of the preparative dispersion, thus permitting covalent bond formation with the amino groups of chitosan when its oxidation to dehydroascorbyl palmitate takes place during microparticle preparation. This preparation method produced microparticles characterized by high loading levels of insulin, completely releasing the drug in about 80 h at an almost constant release rate as determined by spectrophotometric and spectrofluorimetric methods. In contrast, the replacement of ascorbyl palmitate by dehydroascorbyl palmitate provided microparticles incompletely releasing the incorporated drug and characterized by a non-constant release rate over time due to the higher lipophilicity of dehydroascorbyl palmitate which hinders its disposition at the water/oil interface and thus decreases the crosslinking efficiency and increases the lipophilicity of the microparticle surface....Continue Reading

Citations

Dec 6, 2012·Archives of Pharmacal Research·Seong Hoon Jeong
Feb 25, 2014·Biomaterials·Bhanu Prasanth KoppoluDavid A Zaharoff
Sep 5, 2001·Journal of Controlled Release : Official Journal of the Controlled Release Society·J MulhbacherM A Mateescu
Jan 20, 2004·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Naima ZerroukPaola Mura
Apr 20, 2010·The British Journal of Oral & Maxillofacial Surgery·Baogang WangNa Huang
Aug 24, 2001·The Journal of Pharmacy and Pharmacology·A K Singla, M Chawla
Nov 21, 2009·Advanced Drug Delivery Reviews·Maryam AmidiWim E Hennink
Dec 6, 2018·Expert Opinion on Drug Delivery·Sahar Gooneh-FarahaniSeyed Morteza Naghib
Nov 27, 2008·Journal of Materials Science. Materials in Medicine·Ketan PancholiMohan Edirisinghe
Jun 5, 2003·Drug Development and Industrial Pharmacy·Dinesh B ShenoyN Udupa
Sep 2, 1999·Biochemical and Biophysical Research Communications·N PerriconeI Zs-Nagy

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