PMID: 41200Nov 1, 1979

Controlled intravenous bicarbonate and fetal-maternal acid-base balance. I. The primipara

Obstetrics and Gynecology
E CaspiD Modai

Abstract

The effects of a controlled sodium bicarbonate (SB) infusion on the acid-base balance of the primiparous mother and fetus at labor and delivery were evaluated. Two identical groups of primiparas with normal labor and delivery were studied. According to acid-base parameters observed in the mothers and fetuses of a control group, the pharmacologic dynamics, and the space of distribution of SB, 2 mEq/1 kg of total body weight were administered to the mothers of the study group, beginning at a cervical dilation of 6 cm until full dilation occurred. Highly significant changes in pH, base excess (BE), and plasma bicarbonate were observed in both the mothers and fetuses. In the latter, the significant changes appeared after a time lag of about 2 hours. No adverse effects in the mothers and fetuses were observed. The significant reduction of the relative fetal acidosis by the controlled SB infusion justifies further studies on the therapy potentials of this method in high-risk deliveries and during intrapartum fetal distress.

Related Concepts

Evaluation of Acid-base Balance
Embryopathies
Base Excess Measurement
Fetal Distress
Labor (Childbirth)
Pathological Dilatation
Carbonic Acid Ions
Skull Base Neoplasms
Adverse Effects
Sodium Bicarbonate

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