Controlled Ion Release from Novel Polyester/Ceramic Composites Enhances Osteoinductivity

The AAPS Journal
Soheila Ali Akbari GhavimiBret D Ulery

Abstract

Due to the growing number of patients suffering from musculoskeletal defects and the limited supply of and sub-optimal outcomes associated with biological graft materials, novel biomaterials must be created that can function as graft substitutes. For bone regeneration, composite materials that mimic the organic and inorganic phases of natural bone can provide cues which expedite and enhance endogenous repair. Specifically, recent research has shown that calcium and phosphate ions are inherently osteoinductive, so controllably delivering their release holds significant promise for this field. In this study, unique aliphatic polyesters were synthesized and complexed with a rapidly decomposing ceramic (monobasic calcium phosphate, MCP) yielding novel polymer/ceramic composite biomaterials. It was discovered that the fast dissolution and rapid burst release of ions from MCP could be modulated depending on polymer length and chemistry. Also, controlled ion release was found to moderate solution pH associated with polyester degradation. When composite biomaterials were incubated with mesenchymal stems cells (MSCs) they were found to better facilitate osteogenic differentiation than the individual components as evidenced by increased ...Continue Reading

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Citations

Mar 21, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Weiwei LiangXuliang Deng
May 26, 2018·Biomedical Materials·Soheila Ali Akbari GhavimiBret D Ulery
Jun 4, 2017·The AAPS Journal·Aliasger K Salem
Feb 20, 2019·International Journal of Biological Macromolecules·Soheila Ali Akbari GhavimiBret D Ulery

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Methods Mentioned

BETA
nucleic magnetic resonance
NMR
light scattering
Assay
phosphatase assay

Software Mentioned

DROPimage Standard
JMP

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