Controlled Low-Pressure Blast-Wave Exposure Causes Distinct Behavioral and Morphological Responses Modelling Mild Traumatic Brain Injury, Post-Traumatic Stress Disorder, and Comorbid Mild Traumatic Brain Injury-Post-Traumatic Stress Disorder

Journal of Neurotrauma
Amitai ZuckermanHagit Cohen

Abstract

The intense focus in the clinical literature on the mental and neurocognitive sequelae of explosive blast-wave exposure, especially when comorbid with post-traumatic stress-related disorders (PTSD) is justified, and warrants the design of translationally valid animal studies to provide valid complementary basic data. We employed a controlled experimental blast-wave paradigm in which unanesthetized animals were exposed to visual, auditory, olfactory, and tactile effects of an explosive blast-wave produced by exploding a thin copper wire. By combining cognitive-behavioral paradigms and ex vivo brain MRI to assess mild traumatic brain injury (mTBI) phenotype with a validated behavioral model for PTSD, complemented by morphological assessments, this study sought to examine our ability to evaluate the biobehavioral effects of low-intensity blast overpressure on rats, in a translationally valid manner. There were no significant differences between blast- and sham-exposed rats on motor coordination and strength, or sensory function. Whereas most male rats exposed to the blast-wave displayed normal behavioral and cognitive responses, 23.6% of the rats displayed a significant retardation of spatial learning acquisition, fulfilling crite...Continue Reading

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Citations

Sep 27, 2019·Scientific Reports·Ann N HoffmanMichael S Fanselow
Oct 18, 2018·Behavioural Neurology·Peyton TeutschMiranda M Lim
Oct 6, 2020·Frontiers in Neurology·Aswati AravindBryan J Pfister
Nov 17, 2020·Frontiers in Behavioral Neuroscience·Jennifer BlazeFatemeh Haghighi
May 8, 2021·Neuroscience and Biobehavioral Reviews·Claire KostelnikCaroline A Browne
Nov 13, 2021·The European Journal of Neuroscience·Prabahan ChakrabortyFreddy Jeanneteau

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