PMID: 24340989Dec 18, 2013Paper

Controlled myorelaxation in patients with aldosteroma

Anesteziologiia i reanimatologiia
M I Neĭmark, A A Bulganin

Abstract

Purpose of the study was to develop techniques of controlled myorelaxation during surgeries in patients with aldosteroma. 46 patients were involved in the study. Adrenalectomy was performed by videoendoscopy from retroperitoneal access. All patients were operated under general anaesthesia with sevoflurane with obligate monitoring of neuromuscular conduction (NMC). Patients were divided into 4 groups. Myorelaxation in patients of the group 1 (n = 14) was performed by continuous infusion of 0.4 mg/kg/hr rocuronium bromide (esmeron). Myorelaxation in patients of groups 2 (n = 11), 3 (n = 11) and 4 (n = 10) was performed by bolus administration of 0.15 mg/kg/hr esmeron. Patients of groups 1 and 2 were not decurarized. Decurarization in the group 3 was performed by proserin and in the group 4 by sugammadex. In patients of the group 1 esmeron consumption was minimal due to continuous infusion of the drug. Time of neuromuscular blockade recovery (TOF 0.9) was longer than 19 min. Worst data of neuromuscular blockade recovery accrued in the group 2. In patients of the group 3 time of neuromuscular blockade recovery (TOF 0.9) reduced 2.5-3 times in comparison with groups 1 and 2. The use of sugammadex in the group 4 provided almost 4.7 t...Continue Reading

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