Controlled protein delivery in the generation of microvascular networks

Drug Delivery and Translational Research
Jillian W AndrejecskW Mark Saltzman

Abstract

Rapid induction and stabilization of new microvascular networks is essential for the proper functioning of engineered tissues. Many efforts to achieve this goal have used proangiogenic proteins-such as vascular endothelial growth factors-to induce the formation of new microvessels. These proteins have demonstrated promise in improving vascularization, but it is also clear that the spatial and temporal presentation of these signals is important for achieving proper vascular function. Delivery systems that present proteins in a localized and sustained manner, can promote the formation and stabilization of microvascular networks by precisely presenting proangiogenic proteins at desired locations, and for specified durations. Further, these systems allow for some control over the sequence of release of multiple proteins, and it has become clear that such coordination is critical for the development of fully functional and mature vascular structures. This review focuses on the actions of proangiogenic proteins and the innovations in controlled release technologies that precisely deliver these to stimulate microvascular network formation and stabilization.

References

Jun 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·A Antonelli-OrlidgeP A D'Amore
Aug 26, 1998·The Journal of Clinical Investigation·J M EdelbergR D Rosenberg
Jul 27, 1999·International Journal of Cancer. Journal International Du Cancer·V GoedeH G Augustin
Mar 10, 2000·Cytokine & Growth Factor Reviews·M WeinsteinC Deng
Jul 13, 2000·Proceedings of the National Academy of Sciences of the United States of America·J S SchechnerJ S Pober
Oct 25, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·C L AddisonR M Strieter
Jun 8, 2001·Journal of Controlled Release : Official Journal of the Controlled Release Society·A H ZischJ A Hubbell
Jun 8, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·R SalcedoJ J Oppenheim
Nov 2, 2001·Nature Biotechnology·T P RichardsonD J Mooney
Oct 16, 2002·Drug Development and Industrial Pharmacy·K S SoppimathW E Rudzinski
Oct 18, 2002·Trends in Molecular Medicine·Sophie JaverzatAndreas Bikfalvi
Nov 5, 2002·Nature Medicine·Edward J RebarFrank J Giordano
Mar 19, 2003·Circulation·Timothy D HenryUNKNOWN VIVA Investigators
May 3, 2003·Molecular Therapy : the Journal of the American Society of Gene Therapy·Matthew L SpringerHelen M Blau
Jun 5, 2003·Nature Medicine·Rakesh K Jain
Jun 18, 2003·The Journal of Cell Biology·Holger GerhardtChrister Betsholtz
Jul 29, 2003·Cell and Tissue Research·Holger Gerhardt, Christer Betsholtz
Sep 6, 2003·Blood·Marina StraslyFederico Bussolino
Mar 12, 2004·Nature·Naoto KoikeRakesh K Jain
Aug 6, 2004·Endocrine Reviews·Napoleone Ferrara
Sep 18, 2004·Journal of Biomedical Materials Research. Part a·S S KelpkeJ A Thompson
Dec 15, 2004·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·L S BarcelosM M Teixeira
Dec 31, 2004·Proceedings of the National Academy of Sciences of the United States of America·David R EnisJeffrey S Schechner
May 3, 2005·Cytokine & Growth Factor Reviews·Marco PrestaMarco Rusnati
Jun 21, 2005·Nature Biotechnology·Shulamit LevenbergRobert Langer
Jan 28, 2006·Journal of Molecular and Cellular Cardiology·A A KocherS Itescu
Feb 14, 2006·Proceedings of the National Academy of Sciences of the United States of America·Millicent C FordErin B Lavik

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Citations

Mar 20, 2015·Drug Delivery and Translational Research·Agung PurnamaCatherine Le Visage
May 4, 2020·The Journal of Thoracic and Cardiovascular Surgery·Haoran MiaoYiqian Zhang

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