Controlled, randomized study of pain levels in subjects treated with calcium hydroxylapatite premixed with lidocaine for correction of nasolabial folds

Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]
Ellen S MarmurMariano Busso

Abstract

Calcium hydroxylapatite (CaHA) has been administered after nerve block injection of anesthetic agents. This prospective, randomized, split-face, single-blind study (50 subjects) assessed the pain reduction, safety, and effectiveness of premixing CaHA with 2% lidocaine for the treatment of nasolabial folds (NLFs). Subjects were randomized to receive treatment with CaHA alone in one NLF (control) and with CaHA premixed with lidocaine in the other NLF (treatment). Subjects completed pain assessments using a validated visual analog scale at specified time points immediately after injection, 1 hour after injection, and 1 month later. Subjects also indicated relative pain experience and preference assessments. Investigators completed aesthetic assessments at 2 weeks and 1 month. Subjects and investigators recorded adverse events. Subjects reported statistically significantly less pain in the treatment fold than in the control fold and expressed unanimous preference for the treatment injection over the control. Aesthetic results were essentially equivalent for both treatments. Investigators concluded that CaHA premixed with lidocaine results in significant pain reduction during dermal filler injection while maintaining the aesthetic i...Continue Reading

References

Jun 6, 2003·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Rhoda S NarinsStacy Smith
Mar 11, 2004·The Journal of Investigative Dermatology·Susanne Astner, R Rox Anderson
Dec 22, 2007·Plastic and Reconstructive Surgery·Miles H GraivierThomas L Tzikas
Dec 21, 2007·Dermatologic Therapy·Mariano Busso, David Applebaum
Jul 2, 2008·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Mariano Busso, Robert Voigts
Mar 3, 2009·Journal of Cosmetic Dermatology·Kenneth L Edelson
Aug 28, 2009·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Ellen S MarmurJane Y Yoo
Aug 28, 2009·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Ellen S MarmurJane Y Yoo

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Citations

Nov 5, 2010·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Mariano Busso, David J Howell
Nov 5, 2010·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Hema SundaramMelissa Meland
Oct 7, 2010·Clinical Interventions in Aging·Alberto Goldman, Uwe Wollina
Oct 9, 2013·Journal of the American Academy of Dermatology·C William HankeLuitgard G Wiest
Nov 29, 2011·Dermatologic Clinics·Murad AlamMaryam M Asgari
Mar 20, 2014·Journal of Cosmetic Dermatology·Jean-Marie DallaraLaurent Dumas
Jun 18, 2015·American Journal of Clinical Dermatology·Annelyse Cristine BallinAlex Cazzaniga
Mar 2, 2017·Journal of Cosmetic Dermatology·J A Kadouch
Mar 31, 2018·Journal of Cosmetic Dermatology·Michael H Gold, Neil S Sadick
Aug 14, 2019·The Journal of Craniofacial Surgery·Jung Woo ChangJang Hyun Lee
Jun 12, 2013·International Ophthalmology Clinics·M Reza Vagefi
Mar 17, 2020·Journal of Cosmetic Dermatology·Michael H GoldRichard A D'Amico
Sep 26, 2014·Plastic and Reconstructive Surgery·Megan C Jack, Jason N Pozner
Oct 8, 2017·Journal of Cosmetic Dermatology·Jani Aj Van LoghemJob Thuis
Apr 21, 2012·Dermatologic Therapy·Sue Ellen Cox, Chris G Adigun

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