Controlled release formulation of oxycodone in patients with moderate to severe chronic osteoarthritis: a critical review of the literature.

Journal of Pain Research
Robert TaylorJoseph V Pergolizzi

Abstract

Osteoarthritis (OA) is a physically and emotionally debilitating disease that predominantly affects the aging adult population. Current pharmacologic treatment options primarily consist of nonsteroidal anti-inflammatory drugs and/or acetaminophen, but associated side effects, analgesic limitations, especially in the elderly, and the need for around-the-clock analgesia have led physicians to search for alternative analgesics. Opioids have shown effectiveness at mitigating both chronic cancer and noncancer pain, and their ability to be placed into controlled release (CR) formulations suggests that they may prove efficacious for OA patients. One formulation, oxycodone CR, has shown effectiveness in cancer pain patients and in some trials of noncancer low back pain. In this review, the objective was to synthesize the reported findings by researchers in this field and present an up-to-date look at the efficacy, safety, and tolerability of oxycodone CR in OA patients. Public literature databases were searched using specific keywords (eg, oxycodone CR) for studies assessing the efficacy and safety profile of oxycodone CR and its use in patients with OA. A total of eleven articles that matched the criteria were identified, which includ...Continue Reading

References

Aug 12, 1999·Zeitschrift für Rheumatologie·G Nuki
Apr 25, 2001·American Journal of Therapeutics·K D Brandt
Jan 31, 2004·Rheumatology·F C Breedveld
Jan 27, 2006·The Cochrane Database of Systematic Reviews·T E TowheedG Wells
May 24, 2006·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Andrea D FurlanEldon Tunks
Jul 11, 2006·Expert Opinion on Drug Delivery·Paul Sloan, Najib Babul
Mar 21, 2007·Journal of General Internal Medicine·Jaishree HariharanJoan M Neuner
Apr 26, 2007·Clinical Medicine & Research·C K S OngR A Seymour
Jan 1, 2008·Arthritis and Rheumatism·Reva C LawrenceUNKNOWN National Arthritis Data Workgroup
Feb 26, 2008·Osteoarthritis and Cartilage·G A HawkerR Gooberman-Hill
May 23, 2008·American Journal of Therapeutics·Allan Gibofsky, Robert L Barkin
Feb 4, 2009·The Journal of Pain : Official Journal of the American Pain Society·Roger ChouUNKNOWN American Pain Society-American Academy of Pain Medicine Opioids Guidelines Panel
Jun 13, 2009·Arthritis Research & Therapy·Steven B Abramson, Mukundan Attur
Jul 7, 2010·Pain Practice : the Official Journal of World Institute of Pain·James E WildRobert Lange
Aug 12, 2010·Clinics in Geriatric Medicine·Yuqing Zhang, Joanne M Jordan
Aug 12, 2010·Clinics in Geriatric Medicine·Christine M McDonough, Alan M Jette
Sep 3, 2010·Pain Practice : the Official Journal of World Institute of Pain·Joseph V PergolizziKent H Summers
Mar 29, 2011·Hospital Practice·Sheila M SeedAnn M Lynch
Apr 13, 2011·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Nadav FriedmannLynn Webster
Jun 29, 2011·Current Opinion in Rheumatology·Richard F Loeser
Dec 28, 2011·British Journal of Anaesthesia·T I SaariH Schwilden

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Citations

Jan 24, 2012·Journal of Perianesthesia Nursing : Official Journal of the American Society of PeriAnesthesia Nurses·Chris Pasero, Margo McCaffery
Jan 22, 2014·Pain Practice : the Official Journal of World Institute of Pain·Joseph V PergolizziGregory Hess
Nov 28, 2020·Cellular and Molecular Neurobiology·Cherkaouia KibalyCatherine M Cahill

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