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Controlled-release mitochondrial protonophore (CRMP) reverses dyslipidemia and hepatic steatosis in dysmetabolic nonhuman primates

Science Translational Medicine

Oct 2, 2019

Leigh GoedekeGerald I Shulman

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Abstract

Nonalcoholic fatty liver disease (NAFLD) is estimated to affect up to one-third of the general population, and new therapies are urgently required. Our laboratory previously developed a controlled-release mitochondrial protonophore (CRMP) that is functionally liver-targeted and promotes...read more

Mentioned in this Paper

Acetyl Coenzyme A
Diet
Eating
Fatty Liver
Fibrosis
Food
Glucose
Hypertriglyceridemia
Inflammation
Insulin Resistance
23
3
7
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Controlled-release mitochondrial protonophore (CRMP) reverses dyslipidemia and hepatic steatosis in dysmetabolic nonhuman primates

Science Translational Medicine

Oct 2, 2019

Leigh GoedekeGerald I Shulman

PMID: 31578240

DOI: 10.1126/scitranslmed.aay0284

Abstract

Nonalcoholic fatty liver disease (NAFLD) is estimated to affect up to one-third of the general population, and new therapies are urgently required. Our laboratory previously developed a controlled-release mitochondrial protonophore (CRMP) that is functionally liver-targeted and promotes...read more

Mentioned in this Paper

Acetyl Coenzyme A
Diet
Eating
Fatty Liver
Fibrosis
23
3
7

Related Papers

Paper Details
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