Controlled release of a microencapsulated arduous semi-hydrophobic active from coatings: Superhydrophilic polyelectrolyte shells as globally rate-determining barriers

Journal of Controlled Release : Official Journal of the Controlled Release Society
Jonatan BergekLars Nordstierna

Abstract

Polymethylmethacrylate-based microcapsules containing the antimicrobial agent 2-n-octyl-4-isothiazolin-3-one (OIT) decorated by an anchored polyelectrolyte brush consisting of an amphiphilic diblock copolymer of polymethylmethacrylate-block-poly(sodium methacrylate) type have been formulated via a coacervation technique. The polyelectrolyte brush surface provided the microcapsule with a high and stable surface charge density. This enabled further surface modification of the colloidal particle with a thin and dense polyelectrolyte multilayer using the layer-by-layer technique. The addition of the highly charged and hydrophilic polyelectrolyte multilayer assembled on the microcapsule surface resulted in a considerable decrease of the release rate of the encapsulated OIT in aqueous suspension, corresponding to a 40 times reduction of the effective OIT diffusion coefficient in the polymethylmethacrylate matrix. Moreover, the release of encapsulated or freely dispersed OIT from coatings as a function of the matrix density was evaluated and analyzed within the framework of applied diffusion models. Encapsulation of OIT in polyelectrolyte multilayer composite microcapsules was found to significantly prolong the release and render the ...Continue Reading

References

Nov 20, 1998·Journal of Colloid and Interface Science·A Loxley, B Vincent
Aug 23, 2001·Journal of Controlled Release : Official Journal of the Controlled Release Society·X Huang, C S Brazel
Jul 11, 2002·Journal of Controlled Release : Official Journal of the Controlled Release Society·M S Romero-Cano, B Vincent
Aug 15, 2002·International Journal of Pharmaceutics·G Sun, Z Zhang
Jun 1, 2005·Langmuir : the ACS Journal of Surfaces and Colloids·Peter J DowdingPhilippe Bouillot
Oct 8, 2005·Organic & Biomolecular Chemistry·John O MorleyMichael H Charlton
Sep 11, 2007·The Medical Clinics of North America·Rutledge Ellis-Behnke
Sep 17, 2009·Analytical and Bioanalytical Chemistry·Kristian Fog NielsenJens Christian Frisvad
Nov 16, 2011·Chemical Communications : Chem Comm·Andre G SkirtachHelmuth Möhwald
Feb 18, 2012·Langmuir : the ACS Journal of Surfaces and Colloids·Markus Andersson TrojerMagnus Nydén
Mar 13, 2012·Journal of Colloid and Interface Science·Markus Andersson TrojerMagnus Nydén
Apr 25, 2012·Environmental Science & Technology·M BurkhardtT Wangler
Jun 30, 2012·Archives of Environmental Contamination and Toxicology·Per JohanssonHans Blanck
Jul 13, 2013·Bulletin of Environmental Contamination and Toxicology·Ida WendtHans Blanck
Sep 4, 2013·Physical Chemistry Chemical Physics : PCCP·Markus Andersson TrojerKrister Holmberg
Dec 3, 2014·Advances in Colloid and Interface Science·Markus Andersson TrojerMagnus Nydén

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Citations

Aug 18, 2017·Physical Chemistry Chemical Physics : PCCP·Jonatan BergekLars Nordstierna
Nov 21, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Qingqing YaoBailiang Wang
Dec 18, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Hongyan ChenZhanghua Zeng
Jul 11, 2020·Journal of Colloid and Interface Science·Viktor ErikssonLars Nordstierna

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