Controlled release of active as a consequence of the die diameter in solid lipid extrusion

Journal of Controlled Release : Official Journal of the Controlled Release Society
Andrea MichalkP Kleinebudde

Abstract

The aim of the study was the investigation of dependency of the release profile on the original diameters of milled extrudates manufactured by solid lipid extrusion. Different die diameters in the range of 0.3 mm to 5.0 mm were used. The extrudates were milled and sieved. The fractions between 315 microm and 400 microm were investigated within their shape, surface area and dissolution profiles by using the dissolution tester and the disintegration tester for short-time dissolution tests. Different pH-media were used for the release tests: pH 1.2 to imitate release conditions in the stomach and pH 7.4 to imitate conditions in the mouth. The chosen active enrofloxacin, a derivate of 3-quinolinecarboxylic acid, offers different solubilities in these release media. Two conclusions of this study were obtained: In the case of slightly solubility of active in the medium there was no dependency of the released active on the die diameter. If the active was very slightly soluble in the release medium a dependency between the two parameters was found. Having bad tasting actives like enrofloxacin, this achievement has an enormous impact on the manufacturing processes: a reduction of die diameters and therefore reduction of released amount ...Continue Reading

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Citations

Mar 24, 2010·AAPS PharmSciTech·Maike WindbergsPeter Kleinebudde
Jun 7, 2014·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Vandana KharbSuresh Purohit
Jun 15, 2013·Drug Development and Industrial Pharmacy·Mohammed ManiruzzamanDennis Douroumis
Aug 26, 2014·Expert Opinion on Drug Delivery·Mona H Aburahma, Shaimaa M Badr-Eldin
Apr 3, 2012·International Journal of Pharmaceutics·Jonathan VaassenJoerg Breitkreutz
Nov 24, 2011·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Mohammed ManiruzzamanDennis Douroumis
Nov 3, 2011·International Journal of Pharmaceutics·R WitzlebP Kleinebudde
Apr 26, 2011·International Journal of Pharmaceutics·Sinan Güres, Peter Kleinebudde
Oct 14, 2010·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Rieke WitzlebPeter Kleinebudde
Apr 11, 2009·Journal of Controlled Release : Official Journal of the Controlled Release Society·Maike WindbergsPeter Kleinebudde
May 2, 2009·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Maike WindbergsPeter Kleinebudde
Jan 18, 2014·The Journal of Pharmacy and Pharmacology·Lien SaerensThomas De Beer
Nov 5, 2013·The Journal of Pharmacy and Pharmacology·Mohammed ManiruzzamanDennis Douroumis
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Jul 15, 2015·AAPS PharmSciTech·Hemlata PatilMichael A Repka
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Aug 7, 2020·Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences·Matthew Lam, Ali Nokhodchi
Dec 23, 2020·Chemistry and Physics of Lipids·Surojit BanerjeeVikas Anand Saharan

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