Controlled release of an extract of Calendula officinalis flowers from a system based on the incorporation of gelatin-collagen microparticles into collagen I scaffolds: design and in vitro performance

Drug Delivery and Translational Research
Ronald A JiménezMarta R Fontanilla

Abstract

Aiming to develop biological skin dresses with improved performance in the treatment of skin wounds, acellular collagen I scaffolds were modified with polymeric microparticles and the subsequent loading of a hydroglycolic extract of Calendula officinalis flowers. Microparticles made of gelatin-collagen were produced by a water-in-oil emulsion/cross-linking method. Thereafter, these microparticles were mixed with collagen suspensions at three increasing concentrations and the resulting mixtures lyophilized to make microparticle-loaded porous collagen scaffolds. Resistance to enzymatic degradation, ability to associate with the C. officinalis extract, and the extract release profile of the three gelatin-collagen microparticle-scaffold prototypes were assessed in vitro and compared to collagen scaffolds without microparticles used as control. Data indicated that the incorporation of gelatin-collagen microparticles increased the resistance of the scaffolds to in vitro enzymatic degradation, as well as their association with the C. officinalis flower extract. In addition, a sharp decrease in cytotoxicity, as well as more prolonged release of the extract, was attained. Overall results support the potential of these systems to develop...Continue Reading

References

Aug 1, 1998·Journal of Controlled Release : Official Journal of the Controlled Release Society·E S KikkinidesC A Steiner
Aug 15, 1998·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·W Friess
Nov 26, 1998·Archives of Dermatology·D J Brown, A M Dattner
Nov 19, 2003·Advanced Drug Delivery Reviews·M GeigerW Friess
Sep 1, 2004·International Journal of Pharmaceutics·S Freiberg, X X Zhu
Aug 31, 2006·Journal of Biomedical Materials Research. Part a·Alicia J DefailKacey G Marra
Feb 24, 2007·Journal of Herbal Pharmacotherapy·Ethan BaschUNKNOWN Natural Standard Research Collaboration
May 31, 2007·The British Journal of Dermatology·T WongH Navsaria
Jul 12, 2008·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Matthias Schäfer, Sabine Werner
Mar 28, 2009·Journal of the Royal Society, Interface·Yasuhiko Tabata
Jan 25, 2011·International Journal of Pharmaceutics·Van-Thanh TranMarie-Claire Venier-Julienne
Jul 24, 2012·Advanced Drug Delivery Reviews·Boris Michael HolzapfelDietmar Werner Hutmacher
Oct 25, 2012·Biomaterials·Ioannis V Yannas

❮ Previous
Next ❯

Citations

Dec 9, 2015·Drug Delivery and Translational Research·Irit Allon, Elka Touitou
Oct 30, 2016·Therapeutic Delivery·Sanjeev RanjanHélder A Santos
Nov 6, 2018·Drug Delivery and Translational Research·Liliana Gil-CifuentesMarta R Fontanilla
May 17, 2018··Marcella CammarotaMarianna Portaccio

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.