Controlled Release of DEET Loaded on Fibrous Mats from Electrospun PMDA/Cyclodextrin Polymer

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Claudio CeconeMarco Zanetti

Abstract

Electrospun beta-cyclodextrin (βCD)-based polymers can combine a high surface-to-volume ratio and a high loading/controlled-release-system potential. In this work, pyromellitic dianhydride (PMDA)/βCD-based nanosponge microfibers were used to study the capability to host a common insect repellent (N,N-diethyl-3-toluamide (DEET)) and to monitor its release over time. Fibrous samples characterized by an average fibrous diameter of 2.8 ± 0.8 µm were obtained and subsequently loaded with DEET, starting from a 10 g/L diethyl ether (DEET) solution. The loading capacity of the system was assessed via HPLC/UV⁻Vis analysis and resulted in 130 mg/g. The releasing behavior was followed by leaving fibrous DEET-loaded nanosponge samples in air at room temperature for a period of between 24 h and 2 weeks. The releasing rate and the amount were calculated by thermogravimetric analysis (TGA), and the release of the repellent was found to last for over 2 weeks. Eventually, both the chemical composition and sample morphology were proven to play a key role for the high sample loading capacity, determining the microfibers' capability to be applied as an effective controlled-release system.

References

Jan 10, 2002·Journal of Pharmaceutical Sciences·Stefan ProniukJames Blanchard
Dec 2, 2004·Nature Reviews. Drug Discovery·Mark E Davis, Marcus E Brewster
Dec 3, 2005·Biotechnology Progress·Roberto RomiPiero Baglioni
Jun 15, 2006·Tissue Engineering·Quynh P PhamAntonios G Mikos
Apr 15, 2008·Regulatory Toxicology and Pharmacology : RTP·Frank B AntwiRobert K D Peterson
Jan 27, 2010·Biotechnology Advances·Nandana Bhardwaj, Subhas C Kundu
Dec 18, 2012·Beilstein Journal of Organic Chemistry·Francesco TrottaRoberta Cavalli
Jun 5, 2013·International Journal of Pharmaceutics·Thaís Nogueira BarradasClaudia Regina Elias Mansur
Jan 1, 2015·Beilstein Journal of Organic Chemistry·Francesco TrottaDominique Scalarone
Nov 4, 2015·Journal of Parasitology Research·Jong Kwang YoonYoung Bong Kim
Jan 23, 2016·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Shankar SwaminathanFrancesco Trotta
Feb 2, 2016·Wilderness & Environmental Medicine·James H Diaz
Feb 24, 2016·The Medical Clinics of North America·Jonathan D AlpernDavid R Boulware
Jan 4, 2017·Acta Tropica·Johirul IslamPronobesh Chattopadhyay
Jun 25, 2017·International Journal of Pharmaceutics·Fabrizio CalderaFrancesco Trotta
Feb 8, 2018·International Journal of Pharmaceutics·Melanie TavaresEduardo Ricci-Júnior
Aug 1, 2016·The American Journal of Tropical Medicine and Hygiene·Bradley Blitvich

❮ Previous
Next ❯

Methods Mentioned

BETA
thermal treatment
scanning electron microscopy

Software Mentioned

DEET

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Journal of Family Practice
Katherine L Margo
The Journal of the American Association of Nurse Anesthetists
R B Dodd
International Anesthesiology Clinics
C V BERQUIST
Beilstein Journal of Organic Chemistry
Francesco TrottaDominique Scalarone
© 2022 Meta ULC. All rights reserved