Controlled release of diclofenac sodium from polylactide acid-based solid dispersions prepared by hot-melt extrusion

Journal of Biomaterials Science. Polymer Edition
Rong ChenShaoyun Guo

Abstract

In this paper, hot-melt extrusion was applied to prepare drug delivery systems using polylactide acid (PLA) as the matrix. Diclofenac sodium (DS) was used as a model drug. Polyethylene glycol (PEG, molecular weight is 6000) and sodium dodecyl sulfate (SDS) were used as the release rate modifiers. For the PLA/PEG/DS blends, the release of DS was enhanced with higher amounts of PEG and DS. After the addition of SDS to the PLA/PEG/DS blends, the dispersion of DS and PEG was significantly improved. Compared to the PLA/PEG/DS blends with the same drug loading, the drug release behavior of PLA/PEG/DS/SDS was remarkably suppressed due to the presence of SDS. And a controllable linear release of DS was achieved.

References

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infrared spectroscopy

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