Controlled release of DSBP from genipin-crosslinked gelatin thin films

Pharmaceutical Development and Technology
A AbbasiDérick Rousseau

Abstract

Controlled release of a marker drug, 4,4'-bis(2-sulfostyryl) biphenyl (DSBP) from genipin crosslinked gelatin thin films, with application to drug delivery by transdermal patches is studied in this paper. A simple method for fabrication of nano-thin films, using basic lab equipment is introduced. This method consists of two steps: dipping of the substrate in a deposition solution, followed by centrifugation of the substrate. Also, swelling and drug release from thin films is modeled, using the Fick's second law of diffusion. The effect of genipin concentration on release of DSBP molecules from thin films is investigated, experimentally and numerically. The results show that controlled release of DSBP from the genipin-crosslinked gelatin thin films is achieved, using various concentrations of genipin in gelatin.

References

Sep 1, 1967·The Bulletin of Mathematical Biophysics·V Martisovits, S Veis
Jun 6, 2000·Advanced Drug Delivery Reviews·Y Ikada, Y Tabata
Oct 4, 2002·Biomaterials·A BigiK Rubini
Nov 12, 2002·Biomacromolecules·Vittorio CrescenziAnna Taglienti
May 8, 2003·Journal of Biomedical Materials Research. Part a·Huang-Chien LiangHsing-Wen Sung
Jul 19, 2005·Orthodontics & Craniofacial Research·B-H Hu, P B Messersmith
Sep 16, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Mei-Chin ChenHsing-Wen Sung
Sep 24, 2005·Pharmaceutical Development and Technology·Charbel TengrothSven P Jacobsson
Jun 27, 2006·International Journal of Biological Macromolecules·M T NickersonA T Paulson

❮ Previous
Next ❯

Citations

Dec 17, 2011·Micron : the International Research and Review Journal for Microscopy·Goutam ThakurDebdoot Sheet
Feb 19, 2009·The Journal of Chemical Physics·Alireza AbbasiMasahiro Kawaji

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry
Monique A van der VeenThierry Verbiest
Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery
Meng LiXingyan Liu
© 2022 Meta ULC. All rights reserved