Controlled release of odontogenic exosomes from a biodegradable vehicle mediates dentinogenesis as a novel biomimetic pulp capping therapy.

Journal of Controlled Release : Official Journal of the Controlled Release Society
W Benton SwansonPeter X Ma

Abstract

Mineralized enamel and dentin provide protection to the dental pulp, which is vital tissue rich with cells, vasculature, and nerves in the inner tooth. Dental caries left untreated threaten exposure of the dental pulp, providing facile access for bacteria to cause severe infection both in the pulp and systemically. Dental materials which stimulate the formation of a protective dentin bridge after insult are necessary to seal the pulp chamber in an effort to maintain natural dentition and prevent pulpal infection. Dental materials to date including calcium hydroxide paste, mineral trioxide aggregate, and glass ionomer resin, are used with mixed results. Herein we exploited the cell-cell communicative properties of exosomes, extracellular vesicles derived from both mineralizing primary human dental pulp stem cells (hDPSCs) and an immortalized murine odontoblast cell line (MDPC-23), to catalyze the formation of a reactionary dentin bridge by recruiting endogenous stem cells of the dental pulp, through an easy-to-handle delivery vehicle which allows for their therapeutic controlled delivery at the pulp interface. Exosomes derived from both hDPSCs and MDPCs upregulated odontogenic gene expression and increased mineralization in vitr...Continue Reading

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Citations

Nov 1, 2020·Archives of Oral Biology·Sijing YuBo Gao
Jul 22, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Ankita MishraAshok Kumar
Aug 27, 2021·ACS Biomaterials Science & Engineering·Wen QinLi-Na Niu
Dec 24, 2021·Journal of Materials Science. Materials in Medicine·Shan LiWenjun Wang

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