Controlled Release of Plectasin NZ2114 from a Hybrid Silicone-Hydrogel Material for Inhibition of Staphylococcus aureus Biofilm

Antimicrobial Agents and Chemotherapy
Kasper KleinThomas E Andersen

Abstract

Staphylococcus aureus is a major human pathogen in catheter-related infections. Modifying catheter material with interpenetrating polymer networks is a novel material technology that allows for impregnation with drugs and subsequent controlled release. Here, we evaluated the potential for combining this system with plectasin derivate NZ2114 in an attempt to design an S. aureus biofilm-resistant catheter. The material demonstrated promising antibiofilm properties, including properties against methicillin-resistant S. aureus, thus suggesting a novel application of this antimicrobial peptide.

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Oct 19, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Michael StengerThomas E Andersen

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Citations

Apr 27, 2019·Applied Microbiology and Biotechnology·Na YangJianhua Wang
Nov 3, 2020·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Sowmya IndrakumarGünther H J Peters
Feb 4, 2021·Applied Microbiology and Biotechnology·Qingjuan ZhangJianhua Wang
Jul 13, 2021·Frontiers in Microbiology·Kristian StærkThomas Emil Andersen

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