Controlled release of proteins to tissue transplants for the treatment of neurodegenerative disorders

Journal of Pharmaceutical Sciences
M J Mahoney, W M Saltzman

Abstract

Alzheimer's disease involves substantial cholinergic cell deficits; other neurodegenerative diseases involve similar losses of certain cell populations. Optimal therapies may involve tissue replacement coupled with the controlled delivery of appropriate growth factors, such as nerve growth factor, to the graft site. In this review article we describe the kinetics of protein release from three modes of controlled protein delivery to transplants: delivery from a polymer matrix, delivery form polymeric microspheres, and delivery from genetically engineered cells. The efficacy and feasibility of each of these delivery strategies for potential treatment of patients diagnosed with neurodegenerative disorders is discussed.

References

Aug 1, 1990·Bio/technology·M S HoraM E Hudson
May 7, 1990·Brain Research·E M PowellW M Saltzman
Jan 1, 1989·Biophysical Journal·W M Saltzman, R Langer
Mar 1, 1988·The Journal of Comparative Neurology·F H GageS Varon
May 17, 1988·Brain Research·P AebischerP M Galletti
May 9, 1995·Proceedings of the National Academy of Sciences of the United States of America·M H Tuszynski, F H Gage
Jun 7, 1994·Proceedings of the National Academy of Sciences of the United States of America·J F PodusloC T Berg
Apr 1, 1993·Pharmaceutical Research·Y TabataR Langer
May 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·E RonR Langer
Nov 1, 1995·Journal of Neuro-oncology·M MakW M Saltzman
Jan 1, 1984·Pharmaceutical Research·R A Siegel, R Langer

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Citations

Jun 21, 2005·Journal of Materials Science. Materials in Medicine·S KalachandraS Offenbacher
Dec 5, 2006·Journal of Materials Science. Materials in Medicine·S KalachandraJ Webster-Cyriaque
Aug 7, 2003·Dental Materials : Official Publication of the Academy of Dental Materials·D M LinS Offenbacher
Dec 26, 2001·Brain Research. Brain Research Reviews·E H LoN J Abbott
Sep 18, 1997·Trends in Biotechnology·R M Kuntz, W M Saltzman
Oct 18, 2002·Advanced Drug Delivery Reviews·Neeraj KumarAbraham J Domb
Jun 6, 2000·Advanced Drug Delivery Reviews· Mark Saltzman W, S P Baldwin
Jul 27, 2012·Environmental Science & Technology·Asha N SharmaM Todd Walter
Sep 1, 2009·Molecular Pharmaceutics·M GandhiR A Gemeinhart
Apr 17, 2010·Cell Death and Differentiation·P CalissanoN Canu
Mar 6, 1998·Nature Biotechnology·E R Edelman, M Lovich
Jun 21, 2002·Clinical Pharmacokinetics·Alison B Fleming, W Mark Saltzman
Apr 14, 1999·Proceedings of the National Academy of Sciences of the United States of America·M J Mahoney, W M Saltzman
Mar 4, 2005·Drug Delivery·Yun-On LukSai-Lung Law
Oct 6, 2012·Clinics in Plastic Surgery·Jeff J Kim, Gregory R D Evans
May 8, 2007·Advanced Drug Delivery Reviews·Stephanie M Willerth, Shelly E Sakiyama-Elbert
Mar 29, 2011·Journal of Biomedical Materials Research. Part a·Jeremy GriffinKathryn E Uhrich
Jul 23, 2014·Journal of Tissue Engineering and Regenerative Medicine·Andrew S FuGerald M Saidel
Jan 30, 2010·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Silvia Muro
Aug 18, 2004·Journal of Controlled Release : Official Journal of the Controlled Release Society·Zhenhua Li, Leaf Huang
Dec 6, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Alex GoraltchoukMolly S Shoichet
Mar 22, 2016·Expert Opinion on Biological Therapy·Ahad MokhtarzadehMohammad Ramezani
Oct 3, 2001·Nature Biotechnology·M J Mahoney, W M Saltzman
Jul 18, 2002·Nature Reviews. Drug Discovery·W Mark Saltzman, William L Olbricht
Feb 7, 2013·Biomedical Materials·Nima Khadem MohtaramStephanie M Willerth
Oct 16, 2007·Bioconjugate Chemistry·Kraig HaverstickW Mark Saltzman
May 26, 2010·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·M Intakhab AlamM Akbar

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