PMID: 9543819Jan 1, 1997Paper

Controlled release of pseudoephedrine HCl from pellets

Verhandelingen - Koninklijke Academie voor Geneeskunde van België
J Vertommen

Abstract

This study describes the development work on a dosage form, which should release the drug pseudoephedrine HCl over twelve hours. Pellets were chosen as the dosage form. The pellets contained 20, respectively, 45 percent pseudoephedrine HCL and were produced using a high shear mixer-granulator. These pellets were coated in a fluidized bed and in a high shear mixer-granulator equipped with a microwave drying installation. The results of the experiments indicate that it is possible to produce pellets in a high shear mixer-granulator. Strong pellets with a narrow size distribution were obtained. A high shear mixer-granulator appears, therefore, to be a valuable alternative to the more commonly used pellet-forming technique of extrusion-sphere formation. The pellets could be coated as well in a fluidized bed as in a high shear mixer-granulator equipped with a microwave drying installation. A major advantage of the high shear mixer-granulator equipped with a microwave drying installation is the possibility to perform several unit operations such as mixing, pellet formation drying, and coating in one piece of equipment. With respect to the requirement of getting a release of pseudoephedrine HCl over twelve hours, the pellets containin...Continue Reading

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