Controlled release of retinyl acetate from β-cyclodextrin functionalized poly(vinyl alcohol) electrospun nanofibers

Journal of Agricultural and Food Chemistry
Solomon M LemmaPeter Kingshott

Abstract

Retinyl acetate (RA) was effectively incorporated into electrospun nanofibers of poly(vinyl alcohol) (PVA) containing β-cyclodextrin (β-CD) in order to form inclusion complexes for encapsulation to prolong shelf life and thermal stability. The physical and thermal properties of encapsulated RA were determined by scanning electron microscopy (SEM), X-ray diffraction (XRD), and differential scanning calorimetry (DSC). The nanofibers of PVA/RA and PVA/RA/β-CD exhibited bead free average fiber diameters of 264 ± 61 and 223 ± 49 nm, respectively. The surface chemistry of the functional nanofibers was investigated by X-ray photoelectron spectroscopy (XPS). Thermogravimetric analysis (TGA) demonstrated different thermal stabilities between the bioactive and the polymer, with and without β-CD. Square-wave voltammogram peak current changes were used to follow the release kinetics of RA from the nanofibers. Results indicate that RA coated inside PVA/β-CD nanofibers was protected against oxidation much better than RA in PVA nanofibers and should extend the shelf life. In addition, RA encapsulated in the PVA/β-CD had better thermal stability than PVA nanofibers.

References

Jul 6, 2010·Journal of Controlled Release : Official Journal of the Controlled Release Society·M GonnetF Boury
Jan 3, 2012·International Journal of Pharmaceutics·Nasrin Ghouchi-EskandarClive A Prestidge
Dec 4, 2012·Colloids and Surfaces. B, Biointerfaces·Xiaoqiang LiIoannis S Chronakis
Sep 18, 2013·Physical Chemistry Chemical Physics : PCCP·Baghali G Mathapa, Vesselin N Paunov
Sep 1, 2012·Carbohydrate Polymers·Fatma Kayaci, Tamer Uyar

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Citations

Apr 2, 2016·Journal of Agricultural and Food Chemistry·Hualin WangShaotong Jiang
Apr 1, 2016·Journal of the Science of Food and Agriculture·Masumeh Noruzi
Feb 7, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Alejandro CostoyaCarmen Alvarez-Lorenzo
Sep 16, 2017·Rapid Communications in Mass Spectrometry : RCM·Irene PeinadoMatteo Scampicchio
Sep 7, 2019·Journal of Food Biochemistry·Yuchen ZhuYanping Cao
Sep 28, 2017·Journal of Agricultural and Food Chemistry·Peng WenHong Wu

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