Controlled release of vitamin B2 using mesoporous materials functionalized with amine-bearing gate-like scaffoldings

Journal of Controlled Release : Official Journal of the Controlled Release Society
Andrea BernardosJuan Soto

Abstract

A study on the controlled release of vitamin B(2) in pure water from mesoporous silica-based materials containing a pH- and anion-controlled nano-supramolecular gate-like ensembles built up by anchoring suitable polyamines on the external surface is reported (solid S1). This solid contains the vitamin (the delivered molecule) onto the pores, whereas the amine-based gate-like ensemble is anchored on the pore outlets. To obtain solid S1 the mesoporous MCM-41 support was first synthesized using tetraethyl orthosilicate (TEOS) as hydrolytic inorganic precursor and the surfactant hexadecyltrimethylammonium bromide (CTAB) as porogen species. Calcination of the mesostructured phase resulted in the starting solid. Then, first the vitamin and the latter an excess of 3-[2-(2-aminoethylamino)ethylamino]propyl-trimethoxysilane were added to the suspension containing the MCM-41 scaffolding and stirred. Solid S1 was characterized using standard solid state procedures. It was found that the functionalization process and the inclusion of the vitamin on the pores do not modify the mesoporous structure of the starting material. Delivery studies in water were carried out at pH 2 and 7. At pH 2 all the anions studied (sulfate, phosphate, GMP and A...Continue Reading

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