Controlled-release tablets from carrageenans: effect of formulation, storage and dissolution factors

European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V
V K GuptaJ C Price

Abstract

The purpose of this study was to investigate the potential of two carrageenans, iota-carrageenan and lambda-carrageenan for the preparation of controlled-release tablets. Tablets were compressed on a Carver press and the effect of formulation factors, moisture, and storage on the release of theophylline was studied. The effect of sodium chloride in the tablet formulation and a change in the ionic strength of the dissolution media was studied on the release of three model drugs. The release rate increased both with an increase in tablet diameter and increase in drug to carrageenan ratio in the tablets. The two lubricants studied had a negligible effect on the rate of drug release at their commonly used concentrations. Moisture content of carrageenans, storage of tablets at 37 degrees C/75% RH for 3 months, and incorporation of 10% sodium chloride in the tablets did not have any significant effect on the release rate. The change in ionic strength of simulated gastric fluid altered the release rate whereas the ionic strength of simulated intestinal fluid did not have a significant effect on the release rate. Carrageenan tablets were relatively insensitive to small changes in formulation parameters and dissolution conditions.

References

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Citations

May 17, 2005·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Jayanti NerurkarM O Park
Jan 20, 2004·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Cristián TapiaMehrdad Yazdani-Pedram
Jan 10, 2008·AAPS PharmSciTech·Pimwipha PiyakulawatNongnuj Muangsin
Oct 5, 2011·Indian Journal of Pharmaceutical Sciences·S D JaveerPurnima Amin
Aug 24, 2010·International Journal of Pharmaceutics·Matej PavliSaša Baumgartner
Dec 22, 2015·Carbohydrate Polymers·Wenxiu SunJi Zhang
Mar 4, 2006·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Ulrike Bertram, Roland Bodmeier
Jun 28, 2014·Expert Opinion on Drug Delivery·Ali Nokhodchi, Kofi Asare-Addo
May 21, 2014·Pharmaceutical Development and Technology·Rasa KaledaiteRuta Masteikova
Apr 25, 2014·Pharmaceutical Development and Technology·Gyula BuchholczKlára Pintye-Hódi
Nov 26, 2010·International Journal of Pharmaceutics·P DorożyńskiR Jachowicz
Mar 21, 2013·International Journal of Biological Macromolecules·Raghavendra V KulkarniAkram A Naikawadi
Jun 19, 2004·Pharmaceutical Development and Technology·M C BonferoniC Caramella
Jul 28, 2009·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Carien E BenekeJosias H Hamman
Oct 29, 2010·Journal of Molecular Modeling·Anastasios G Papadopoulos, Michael P Sigalas
Oct 20, 2010·Pharmaceutical Development and Technology·W A Felician, E S Ghaly
Nov 27, 2020·Marine Drugs·Edisson-Mauricio Pacheco-QuitoMaría-Dolores Veiga

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