PMID: 9549354Apr 29, 1998Paper

Controlled release using temperature-responsive poly(N-isopropylacrylamide) gel

Nihon rinsho. Japanese journal of clinical medicine
R Yoshida

Abstract

Poly (N-isopropylacrylamide) (PNIPAAm) gels were found to undergo discontinuous swelling-deswelling changes in response to a limited alteration in external temperatures. By utilizing such as thermosensitive characteristic of the PNIPAAm gel, controlled drug release was studied extensively. Drug release profiles were well established in connection with the temperature dependence of swelling ratio for the gel. The thermal regulation of the swelling degree of the gel made it possible for us to design several ways for performing a unique drug release profile such as a "pulsatile" or "on-off" release of indomethacin. Attempts to develop a more excellent drug release system have being made through studies of molecular design and synthesis for PNIPAAm-based thermosensitive gels.

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Controlled Release : Official Journal of the Controlled Release Society
Jing-Yi WuYi-Yan Yang
Journal of Controlled Release : Official Journal of the Controlled Release Society
Mio Hidaka, R Yoshida
Journal of Controlled Release : Official Journal of the Controlled Release Society
R YoshidaYoko Murase
© 2022 Meta ULC. All rights reserved