Controlled-releasing hydrogen sulfide donor based on dual-modal iron oxide nanoparticles protects myocardial tissue from ischemia-reperfusion injury

International Journal of Nanomedicine
Wenshuo WangLai Wei

Abstract

Hydrogen sulfide (H2S) has shown promising therapeutic benefits in reversing a variety of pathophysiological processes in cardiovascular system, including myocardial ischemia-reperfusion (IR) injury. However, the achievement of controlled and sustained release of H2S has been a technical bottleneck that limits the clinical application of the gas molecule. The current study describes the development of mesoporous iron oxide nanoparticles (MIONs) which were loaded with diallyl trisulfide (DATS), a H2S donor compound, and calibrated by stimulated Raman scattering/transient absorption. The synthesized MIONs were characterized with excellent mesoporosity and a narrow size distribution, which enabled them to slow down the release of H2S to a suitable rate and prolong the plateau period. The controlled-release feature of DATS-MIONs resulted in little adverse effect both in vitro and in vivo, and their protective effect on the heart tissue that underwent IR injury was observed in the mouse model of myocardial ischemia. The rapid biodegradation of DATS-MIONs was induced by Kupffer cells, which were specialized macrophages located in the liver and caused limited hepatic metabolic burden. The sustained-release pattern and excellent biocom...Continue Reading

Citations

Mar 30, 2019·American Journal of Physiology. Heart and Circulatory Physiology·Sumit KarParas K Mishra
Mar 12, 2020·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Lin RenDongmei Wang
May 7, 2020·Antioxidants & Redox Signaling·Gabriel Gojon, Guillermo A Morales
Sep 17, 2020·Journal of Drug Targeting·Cuican LiZhou Xiaohui
Mar 7, 2021·International Journal of Molecular Sciences·Yi-Zhen WangDong-Dong Wu
Aug 18, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Joana Claudio PierettiAmedea Barozzi Seabra

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