PMID: 8451010Mar 1, 1993Paper

Controlled study of the antiparkinsonian activity and tolerability of cabergoline

Neurology
J T HuttonM A Brewer

Abstract

Cabergoline, a new ergoline derivative, is a D2-specific dopaminergic agonist that is more potent and longer-acting than other agonist agents. We conducted a randomized, double-blind study of increasing doses of cabergoline taken once a day. Twenty-five patients with Parkinson's disease taking stable doses of levodopa began cabergoline at 0.5 mg. The dose was escalated at weekly intervals to 1.0 mg in 19 patients, 1.5 mg in 14 patients, 2.0 mg in nine patients, and 2.5 mg in four patients. Treatment continued for 8 weeks after titration. Unified Parkinson's Disease Rating Scale scores, Hoehn and Yahr stage of disease, and computerized measures of motor performance improved significantly with cabergoline treatment. Dose-response effects were not significant. No serious adverse experiences occurred during the 13-week trial, and the side-effect profile mirrored other dopaminergic agonists. Cabergoline appears to be a promising agent in the treatment of Parkinson's disease.

Citations

Sep 1, 1995·Movement Disorders : Official Journal of the Movement Disorder Society·R InzelbergA D Korczyn
Sep 1, 1996·Movement Disorders : Official Journal of the Movement Disorder Society·G GeminianiT Caraceni
Aug 14, 2003·Parkinsonism & Related Disorders·Fabrizio Stocchi
Jul 2, 2008·Parkinsonism & Related Disorders·J T HuttonJ W Elias
Oct 6, 2000·Clinical Neuropharmacology·A Hadj TaharP J Bédard
Feb 10, 2006·Expert Review of Neurotherapeutics·Ubaldo Bonuccelli, Nicola Pavese
Oct 18, 2007·Expert Review of Neurotherapeutics·Ubaldo Bonuccelli, Nicola Pavese

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