Controlled synthesis, characterization, and application of iron oxide nanoparticles for oral delivery of insulin.

Lasers in Medical Science
Alemu KebedeA V Gholap

Abstract

Impurity-free, controlled synthesis of iron oxide nanoparticle, in ultrapure water and chitosan, using laser ablation technique and its application for type II diabetes management through oral delivery of insulin-loaded iron oxide-chitosan nanocomposite is presented. The purity of the nanoparticle is monitored by laser-induced breakdown spectroscopy technique. The synthesized iron oxide nanoparticle was characterized by UV/Vis absorption spectroscopy, and morphological study was performed by scanning electron microscope. The intensity of absorption peak and wavelength corresponding to peak of the nanoparticle prepared in water and chitosan is dependent on the laser energy used for ablation purpose. Red shift in the absorption peak wavelength was observed by increasing laser energy. In addition to red shift, an increase in intensity of absorption peak was also seen when ablating laser energy was increased. The appearance of a weak peak around 295 nm was observed in iron oxide-chitosan nanocomposite. The spherical shape of the nanoparticle synthesized at the lower laser energy has gradually changed to triangular and irregular shaped structures as ablating laser energy was increased. The spherical nanoparticles loaded with insulin...Continue Reading

References

Aug 12, 2008·Biosensors & Bioelectronics·Ajeet KaushikB D Malhotra
Jan 20, 2009·Recent Patents on Drug Delivery & Formulation·Tin W Wong
May 25, 2010·Colloids and Surfaces. B, Biointerfaces·Ratan SarkarG B Talapatra
Feb 15, 2011·Lasers in Medical Science·Ashok Kumar PathakG D Baruah
May 3, 2011·Lasers in Medical Science·Vivek Kumar Singh, Awadhesh Kumar Rai

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Citations

Nov 10, 2015·Expert Opinion on Drug Delivery·Khalid Al RubeaanSanjay Jayavanth
Jun 13, 2015·Drug Delivery·Yue Yuan LuoYu Ping Li
Oct 28, 2015·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Gozde S DemirerSeda Kizilel
Aug 11, 2021·Advanced Drug Delivery Reviews·Rajeswari RaguramanRajagopal Ramesh

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