PMID: 6230296Mar 1, 1984Paper

Controlled trial of a thymic hormone extract (Thymostimulin) in 'autoimmune' chronic active hepatitis

Gut
J E HegartyR Williams

Abstract

A randomised controlled trial of thymic hormone extracts (Thymostimulin) (1 mg/kg/day for seven days; 1 mg/kg/weekly thereafter) was undertaken in 30 patients (21 women, nine men) with treated, apparently inactive 'autoimmune' chronic active hepatitis during withdrawal of maintenance corticosteroid and azathioprine therapy. Reactivation of disease occurred in 26 patients (86%) during or after treatment withdrawal and was as frequent in the Thymostimulin treated (11 of 13; 84%) and untreated (15 of 17; 88%; p greater than 0.05) groups. Reactivation of disease was accompanied by a severe defect in concanavalin A induced suppressor cell activity, the magnitude of which was similar in the Thymostimulin treated and untreated groups (mean % suppression = 16.4 and 3.2 respectively; p greater than 0.05 vs 84.4 in control subjects). Further studies assessing the optimal dose, duration of treatment, and mode of administration are required to establish a therapeutic role for thymic hormone extracts in 'autoimmune' chronic active hepatitis.

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Citations

Jun 1, 1993·Journal of General Internal Medicine·P D King
Sep 1, 1991·Gut·P J Johnson, I G McFarlane
Jun 2, 2001·Clinics in Liver Disease·R G Gish, A Mason
Apr 20, 2010·Journal of Hepatology·Mieke M H LamersJoost P H Drenth
Apr 5, 1986·British Medical Journal·G Alexander, R Williams
Dec 21, 2002·Alimentary Pharmacology & Therapeutics·J MedinaR Moreno-Otero
Feb 1, 1995·Digestive Diseases and Sciences·A J Czaja
Oct 4, 2017·World Journal of Gastroenterology : WJG·Benedetta Terziroli Beretta-PiccoliDiego Vergani

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