PMID: 6230296Mar 1, 1984Paper

Controlled trial of a thymic hormone extract (Thymostimulin) in 'autoimmune' chronic active hepatitis

J E HegartyR Williams


A randomised controlled trial of thymic hormone extracts (Thymostimulin) (1 mg/kg/day for seven days; 1 mg/kg/weekly thereafter) was undertaken in 30 patients (21 women, nine men) with treated, apparently inactive 'autoimmune' chronic active hepatitis during withdrawal of maintenance corticosteroid and azathioprine therapy. Reactivation of disease occurred in 26 patients (86%) during or after treatment withdrawal and was as frequent in the Thymostimulin treated (11 of 13; 84%) and untreated (15 of 17; 88%; p greater than 0.05) groups. Reactivation of disease was accompanied by a severe defect in concanavalin A induced suppressor cell activity, the magnitude of which was similar in the Thymostimulin treated and untreated groups (mean % suppression = 16.4 and 3.2 respectively; p greater than 0.05 vs 84.4 in control subjects). Further studies assessing the optimal dose, duration of treatment, and mode of administration are required to establish a therapeutic role for thymic hormone extracts in 'autoimmune' chronic active hepatitis.


Nov 1, 1978·Clinical Immunology and Immunopathology·R E WolfM Ziff
Apr 1, 1979·The Journal of Clinical Investigation·R E Wolf
Jan 9, 1975·The New England Journal of Medicine·D W WaraA J Ammann
Feb 28, 1975·Annals of the New York Academy of Sciences·N TalalR Goldblum
Nov 18, 1982·The New England Journal of Medicine·K T Nouri-AriaR Williams
Jan 15, 1981·The New England Journal of Medicine·M E OsbandR Parkman
Jul 1, 1980·The Journal of Allergy and Clinical Immunology·A S Fauci
Jul 1, 1982·Pediatric Research·E G Davies, R J Levinsky
Jan 1, 1981·Progress in Clinical and Biological Research·A S Fauci
Oct 23, 1980·Clinica Chimica Acta; International Journal of Clinical Chemistry·P J LisiM Schiffman

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