PMID: 336378Oct 14, 1977Paper

Controlled trial of acebutolol in hypertension

European Journal of Clinical Pharmacology
L HanssonM Holm


Acebutolol, a new cardioselective beta-adrenoceptor blocking agent, has been evaluated for the treatment of hypertension. Thirty eight previously untreated male patients with essential hypertension received placebo treatment during a 4-week run-in period, and then they were randomly (double-bind) allocated either to continued placebo treatment for three 4-week periods or to treatment with acebutolol 400, 600, and 1200 mg daily, respectively, for three 4-week periods. Blood pressure and heart rate were recorded at the end of each 4-week period. Treatment with acebutolol produced statistically significant reductions in blood pressure and heart rate as compared to the placebo regimen.


May 17, 1975·British Medical Journal·L HanssonA Westerlund
Jun 1, 1973·British Journal of Pharmacology·B BasilD R Maxwell
Apr 1, 1972·Klinische Wochenschrift·L HanssonB Hood
Jun 29, 1974·British Medical Journal·E C Huskisson, J A Wojtulewski
Jun 1, 1972·American Heart Journal·F J ZachariasB G Wall
Jan 4, 1969·British Medical Journal·B N Prichard, P M Gillam
Mar 1, 1964·Clinical Pharmacology and Therapeutics·G SCHROEDER, L WERKOE
Sep 19, 1964·British Medical Journal·B N PRICHARD, P M GILLAM

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Jan 1, 1980·European Journal of Clinical Pharmacology·M ThibonnierP Corvol
Dec 18, 1978·European Journal of Clinical Pharmacology·M A MartinA J Smith
Jan 1, 1980·Pharmacology & Therapeutics·B N Prichard, C W Owens
May 1, 1985·American Heart Journal·G De BonoA J Summers
Mar 1, 1984·The American Journal of Cardiology·B TrimarcoM Condorelli
Feb 1, 1982·British Journal of Clinical Pharmacology·P A MitenkoJ J Brossard
Nov 28, 2014·The Cochrane Database of Systematic Reviews·Gavin W K WongJames M Wright
Apr 1, 1982·British Journal of Clinical Pharmacology·M ThibonnierJ Menard

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