PMID: 782375Mar 1, 1976Paper

Controlled trial of continuous inflating pressure for hyaline membrane disease

Archives of Disease in Childhood
G M DurbinP D Wimberley

Abstract

A controlled trial of elective intervention with continuous inflating pressure (CIP) was performed in infants with severe hyaline membrane disease who weighed more than 1000 g at birth. Infants entered the trial if their arterial oxygen tension (PaO2) fell below 60 mmHg while breathing a fractional inspired oxygen concentration (F1O2) greater than 0-95. 11 out of 12 infants in the CIP-treated group and 10 out of 12 in the control group survived. 7 treated and 6 control infants required mechanical ventilation. When CIP was started the Pao2 of the treated infants increased, and they breathed high concentrations of oxygen for a significantly shorter period than the control infants. During the 31-month duration of the trial 107 other infants with severe hyaline membrane disease were admitted who did not meet the criteria for entry to the trial. 37 survived after breathing high concentrations of oxygen (F1O2 greater than 0-60) spontaneously without any ventilatory assistance, and the remaining 70 infants were already being ventilated on their arrival in the unit, usually because they had required mechanical ventilation during transfer from other hospitals. The neonatal survival rate for those infants born in this hospital during the...Continue Reading

References

Jul 1, 1974·Archives of Disease in Childhood·E O Reynolds, A Taghizadeh
Aug 9, 1973·The New England Journal of Medicine·V Chernick
Mar 1, 1974·Archives of Disease in Childhood·G Caliumi-PellegriniG Bucci
Oct 1, 1974·Archives of Disease in Childhood·J D Baum, N R Roberton
Jun 17, 1971·The New England Journal of Medicine·G A GregoryW K Hamilton

❮ Previous
Next ❯

Citations

Apr 25, 1979·European Journal of Pediatrics·N W SvenningsenH Ahlström
Aug 27, 1981·The New England Journal of Medicine·J C SinclairD L Sackett
Feb 1, 1994·Acta Paediatrica·J E Pedersen, K Nielsen
Mar 1, 1976·Archives of Disease in Childhood·N R Robertson
May 1, 1977·Archives of Disease in Childhood·L P AllenP D Wimberley
Nov 1, 1979·Archives of Disease in Childhood·N R Roberton
Jun 25, 2013·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Hany AlyMaide Ozen
Dec 5, 2002·Seminars in Neonatology : SN·Richard A Polin, Rakesh Sahni
May 1, 2001·Journal of Paediatrics and Child Health·A M De Klerk, R K De Klerk
Jul 5, 2015·The Cochrane Database of Systematic Reviews·Jacqueline J HoPeter G Davis
Aug 1, 1986·Anaesthesia and Intensive Care·A W DuncanD R Hillman
Mar 1, 1979·Australian Paediatric Journal·A D Milner
Oct 16, 2020·The Cochrane Database of Systematic Reviews·Jacqueline J HoPeter G Davis

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Landau-Kleffner Syndrome

Landau Kleffner syndrome (LKS), also called infantile acquired aphasia, acquired epileptic aphasia, or aphasia with convulsive disorder, is a rare childhood neurological syndrome characterized by the sudden or gradual development of aphasia (the inability to understand or express language) and an abnormal electroencephalogram. Discover the latest research on LKS here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.