PMID: 326199May 1, 1977Paper

Controlled trial of continuous positive airway pressure given by face mask for hyaline membrane disease

Archives of Disease in Childhood
L P AllenP D Wimberley


A controlled trial of elective intervention with continuous positive airway pressure (CPAP) was performed on 24 infants with hyaline membrane disease whose arterial oxygen tension (Pao2) fell below 8kPa (60 mmHg) while they were breathing a fractional inspired oxygen concentration (F1O2) greater than 0.60. A face mask was used to apply the CPAP. The progress of the 12 infants who were treated on entry to the trial was compared with that of 12 infants who were treated later. All 12 infants in the early-intervention group and 8 infants in the late-intervention group survived. When CPAP was started, Pao2 increased and the early-treated infants breathed high concentrations of oxygen for a shorter period than the late-treated infants. The 4 infants in the early-intervention group who required mechanical ventilation needed lower mean airway pressures to achieve satisfactory gas exchange than the 7 ventilated infants in the late-intervention group. We conclude that a Pao2 less than 8 kPa while breathing an F1o2 greater than 0.60 is an adequate indication for giving CPAP in hyaline membrane disease, and that early intervention with CPAP allows infants who go on to require mechanical ventilation to be ventilated at lower pressures.

Associated Clinical Trials


Mar 1, 1976·Archives of Disease in Childhood·N R Robertson
Mar 1, 1976·Archives of Disease in Childhood·G M DurbinP D Wimberley
Jul 1, 1974·Archives of Disease in Childhood·E O Reynolds, A Taghizadeh
Aug 1, 1972·Archives of Disease in Childhood·C K BanerjeeJ S Wigglesworth
Aug 9, 1973·The New England Journal of Medicine·V Chernick
Mar 1, 1974·Archives of Disease in Childhood·G Caliumi-PellegriniG Bucci
Oct 1, 1974·Archives of Disease in Childhood·J D Baum, N R Roberton
Mar 1, 1974·Archives of Disease in Childhood·R HuchA Huch
Jun 17, 1971·The New England Journal of Medicine·G A GregoryW K Hamilton
Feb 16, 1967·The New England Journal of Medicine·W H NorthwayD Y Porter

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