PMID: 326199May 1, 1977Paper

Controlled trial of continuous positive airway pressure given by face mask for hyaline membrane disease

Archives of Disease in Childhood
L P AllenP D Wimberley

Abstract

A controlled trial of elective intervention with continuous positive airway pressure (CPAP) was performed on 24 infants with hyaline membrane disease whose arterial oxygen tension (Pao2) fell below 8kPa (60 mmHg) while they were breathing a fractional inspired oxygen concentration (F1O2) greater than 0.60. A face mask was used to apply the CPAP. The progress of the 12 infants who were treated on entry to the trial was compared with that of 12 infants who were treated later. All 12 infants in the early-intervention group and 8 infants in the late-intervention group survived. When CPAP was started, Pao2 increased and the early-treated infants breathed high concentrations of oxygen for a shorter period than the late-treated infants. The 4 infants in the early-intervention group who required mechanical ventilation needed lower mean airway pressures to achieve satisfactory gas exchange than the 7 ventilated infants in the late-intervention group. We conclude that a Pao2 less than 8 kPa while breathing an F1o2 greater than 0.60 is an adequate indication for giving CPAP in hyaline membrane disease, and that early intervention with CPAP allows infants who go on to require mechanical ventilation to be ventilated at lower pressures.

Associated Clinical Trials

References

Mar 1, 1976·Archives of Disease in Childhood·N R Robertson
Mar 1, 1976·Archives of Disease in Childhood·G M DurbinP D Wimberley
Jul 1, 1974·Archives of Disease in Childhood·E O Reynolds, A Taghizadeh
Aug 1, 1972·Archives of Disease in Childhood·C K BanerjeeJ S Wigglesworth
Aug 9, 1973·The New England Journal of Medicine·V Chernick
Mar 1, 1974·Archives of Disease in Childhood·G Caliumi-PellegriniG Bucci
Oct 1, 1974·Archives of Disease in Childhood·J D Baum, N R Roberton
Mar 1, 1974·Archives of Disease in Childhood·R HuchA Huch
Jun 17, 1971·The New England Journal of Medicine·G A GregoryW K Hamilton
Feb 16, 1967·The New England Journal of Medicine·W H NorthwayD Y Porter

❮ Previous
Next ❯

Citations

Apr 25, 1979·European Journal of Pediatrics·N W SvenningsenH Ahlström
Feb 1, 1994·Acta Paediatrica·J E Pedersen, K Nielsen
Feb 1, 1978·Archives of Disease in Childhood·L P AllenP D Wimberley
Apr 1, 1991·Archives of Disease in Childhood·W Tarnow-Mordi
Oct 21, 1978·British Medical Journal·I ChalmersO P Gray
Mar 15, 2006·Clinics in Perinatology·Louis P Halamek, Colin Morley
Dec 5, 2002·Seminars in Neonatology : SN·Richard A Polin, Rakesh Sahni
Jun 23, 2016·Pediatric Pulmonology·Kenji HishikawaYushi Ito
Mar 10, 2012·The Journal of Pediatrics·Jose L TapiaUNKNOWN South American Neocosur Network
May 1, 2001·Journal of Paediatrics and Child Health·A M De Klerk, R K De Klerk
Sep 1, 1979·Australian Paediatric Journal·V Y Yu, E Hollingsworth
Oct 16, 2020·The Cochrane Database of Systematic Reviews·Jacqueline J HoPeter G Davis

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Landau-Kleffner Syndrome

Landau Kleffner syndrome (LKS), also called infantile acquired aphasia, acquired epileptic aphasia, or aphasia with convulsive disorder, is a rare childhood neurological syndrome characterized by the sudden or gradual development of aphasia (the inability to understand or express language) and an abnormal electroencephalogram. Discover the latest research on LKS here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.