PMID: 6405607Jun 1, 1983Paper

Controlled trial of copper supplementation during the recovery from marasmus

The American Journal of Clinical Nutrition
C Castillo-DuránR Uauy

Abstract

To evaluate copper nutritional status and the effect of a Cu supplement during recuperation, 27 marasmic infants were selected on admission to the nutrition recovery center at the Instituto de Nutrición y Tecnología de los Alimentos. Thirteen infants received 80 micrograms/kg/day of copper supplement as sulphate and the remaining a placebo. They were paired by birth weight, age, and sex. Anthropometric indices, complete blood count, ceruloplasmin, and Cu were measured on admission and at monthly intervals. Superoxide dismutase activity was measured in hypocupremic infants and was found to be low. The mean +/- SE Cu levels on admission were 127 +/- 10 micrograms/dl for the supplemented group and 137 +/- 10 micrograms/dl for the control. We found an increase in plasma Cu to 159 and 162 micrograms/dl on days 30 and 60 in the supplement group, and a significant decrease after day 30 in the placebo group. The ceruloplasmin levels followed this trend. Hypocupremia was found in 30% of the placebo group and none in the supplement group. The placebo group had a significantly higher prevalence of severe lower respiratory infections. It is concluded that a significant proportion of marasmic infants fed a milk-based diet present, during re...Continue Reading

Citations

Sep 1, 1985·Acta paediatrica Scandinavica·A RodríguezC Castillo-Durán
Jul 6, 2000·Pediatrics International : Official Journal of the Japan Pediatric Society·M M TatliA Atas
Aug 15, 2000·Journal of Pediatric Gastroenterology and Nutrition·M OlivaresR Uauy
Dec 17, 2009·Food and Nutrition Bulletin·Michael H Golden
Jan 1, 1993·Annals of Tropical Paediatrics·A A SiveH D Heese
Mar 13, 2018·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Kunal GuptaSanjiv B Amin
Sep 1, 1994·Acta Paediatrica. Supplement·P J Aggett
Mar 3, 1998·Nutrition Reviews·M L Failla, R G Hopkins
Mar 17, 2010·Journal of Neurology·Stephan R Jaiser, Gavin P Winston
May 17, 2008·Biological Trace Element Research·Gerardo WeisstaubMagdalena Araya
Apr 1, 2017·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Callum Livingstone
Jan 1, 1985·Journal of the American College of Nutrition·N W Solomons
Aug 21, 2013·SpringerPlus·Kiri Hashimu JaryumBarbara Stoecker
Oct 17, 2012·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Allison Beck Blackmer, Elizabeth Bailey
Apr 1, 2017·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Callum Livingstone
Jun 1, 1985·Infection and Immunity·O A LukasewyczP Marder

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