PMID: 6108445Dec 13, 1980Paper

Controlled trial of Pseudomonas immunoglobulin and vaccine in burn patients

Lancet
R J JonesJ L Gupta

Abstract

In a controlled trial burn patients at risk of Pseudomonas aeruginosa septicaemia were passively immunised with an immunoglobulin prepared from plasma from healthy human volunteers vaccinated with a polyvalent pseudomonas vaccine; passively immunised and vaccinated; or only vaccinated. In children the mortality was lowest in those passively immunised (0%, 0/18); it was 21% (9/42) in controls. In adults the mortality rate of those receiving immunoglobulin or vaccine was 10% (3/30) or 8.3% (5/60), respectively, compared with 36% (22/61) in controls. Combined vaccine and immunoglobulin treatment gave rather less protection (mortality 13.6%, 3/22) than vaccine alone. Pseudomonas infection of burns was less common in patients who received immunoglobulin than in vaccinated or control patients.

References

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Citations

Oct 2, 1989·Klinische Wochenschrift·P Berlit
Jun 1, 1995·Burns : Journal of the International Society for Burn Injuries·E B Jones
Oct 1, 1982·Journal of Biological Standardization·B MarkmanC R Salenstedt
Oct 1, 1985·Journal of Biological Standardization·P Bannister, J Mellor
Dec 17, 1983·Lancet·G A YoungF M Parsons
Oct 1, 1984·The Journal of Hygiene·E A Roe, R J Jones
Sep 1, 1984·Annals of Surgery·C W NohrJ L Meakins
Sep 26, 2001·The Journal of Burn Care & Rehabilitation·I A Holder
Dec 1, 1986·Journal of Clinical Pathology·R C MatthewsS Tabaqchali
Jul 16, 2005·Expert Opinion on Biological Therapy·E Sedlak-WeinsteinA R Foxwell
Sep 24, 2011·Human Vaccines·Anurag SharmaStefan Worgall
Jun 1, 1981·The Journal of Hospital Infection·R J Jones
Jan 1, 1992·Burns : Journal of the International Society for Burn Injuries·J C Lawrence
Jun 1, 1989·Burns : Journal of the International Society for Burn Injuries·J D Frame, A S Everitt
Feb 5, 2008·Vaccine·Gerd Döring, Gerald B Pier
Jul 1, 1997·The Pediatric Infectious Disease Journal·E R Stiehm
Apr 29, 2005·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Robert L Sheridan
Jul 1, 1983·Scottish Medical Journal·R Crawford, R Mitchell
May 1, 1982·Annals of Clinical Biochemistry·S L GaffinJ D Conradie

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