PMID: 9169302May 1, 1997Paper

Controlled trials of inositol in psychiatry

European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology
J Levine

Abstract

Inositol is a simple polyol precursor in a second messenger system important in the brain. Cerebrospinal fluid inositol has been reported as decreased in depression. A double-blind controlled trial of 12 g daily of inositol in 28 depressed patients for four weeks was performed. Significant overall benefit for inositol compared to placebo was found at week 4 on the Hamilton Depression Scale. No changes were noted in hematology, kidney or liver function. Since many antidepressants are effective in panic disorder, twenty-one patients with panic disorder with or without agoraphobia completed a double-blind, placebo-controlled, four week, random-assignment crossover treatment trial of inositol 12 g per day. Frequency and severity of panic attacks and severity of agoraphobia declined significantly with inositol compared to placebo. Side-effects were minimal. Since serotonin re-uptake inhibitors benefit obsessive compulsive disorder (OCD) and inositol is reported to reverse desensitization of serotonin receptors, thirteen patients with OCD completed a double-blind controlled crossover trial of 18 g inositol or placebo for six weeks each. Inositol significantly reduced scores of OCD symptoms compared with placebo. A controlled double-b...Continue Reading

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Citations

Mar 23, 2001·The International Journal of Eating Disorders·D GelberR H Belmaker
Nov 21, 2007·Bulletin of Experimental Biology and Medicine·R SolomoniaV Pkhakadze
May 5, 2001·Pharmacology & Therapeutics·S V ArgyropoulosD J Nutt
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