PMID: 9183777Jan 1, 1997Paper

Controlling blood glucose: insights from an engineering control systems perspective

Medical Informatics = Médecine Et Informatique
D R Worthington

Abstract

In order to discern areas of potential improvement in various aspects of glycaemic control for patients with insulin dependent (type 1) diabetes mellitus, blood glucose control is analysed in the light of general engineering feedback control systems theory. This approach is based on models of the system being controlled, using appropriate control strategies. The models presently used for glycaemic control are analysed from this perspective, revealing certain limitations that they impose on the control strategies that use them. Current type 1 diabetes regimens are evaluated for the ease with which they may be analysed mathematically, suggesting areas where improvements in control may be effected by simplifying calculation of appropriate insulin quantities. A new model of undergraded insulin action, derived from established insulin action profiles, along with a control strategy which flexibly extends the basal/bolus regimen using patient-specific parameters, is proposed. This may provide the information needed to enable prediction of expected glycaemia several hours into the future, thereby enabling earlier corrective action to be taken should it fail outside the target range, and in turn potentially reduce the degree and frequen...Continue Reading

References

Jul 1, 1990·Computer Methods and Programs in Biomedicine·D R Worthington
Dec 1, 1990·Diabetes Care·I B HirschJ S Skyler
Jul 1, 1988·Diabetes Care·M P GoldenO P Schumacher
Nov 1, 1985·Diabetes Care·A SchiffrinA M Albisser
Jul 1, 1980·Medical & Biological Engineering & Computing·C CobelliA Salvan
Dec 1, 1994·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·M E Trautmann
Sep 30, 1993·The New England Journal of Medicine·UNKNOWN Diabetes Control and Complications Trial Research GroupC Siebert
Aug 1, 1996·Computer Methods and Programs in Biomedicine·E D Lehmann, T Deutsch
Jan 4, 1997·Lancet·A H Barnett, D R Owens
Jan 1, 1997·Medical Informatics = Médecine Et Informatique·D R Worthington

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Citations

Jul 27, 2001·Diabetes Technology & Therapeutics·E Colloff
Jan 1, 1997·Medical Informatics = Médecine Et Informatique·E D Lehmann
Jan 1, 1997·Medical Informatics = Médecine Et Informatique·D R Worthington

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