Controlling cardiac arrhythmias: to delay conduction or to prolong refractoriness

Cardiovascular Drugs and Therapy
B N Singh

Abstract

Recent data with encainide and flecainide (CAST study) question the benefit of reducing premature ventricular contractions in survivors of myocardial infarction. Proarrhythmic mechanisms might include excessive slowing of conduction. In patients with supraventricular tachycardias, proarrhythmic effects of Class 1c agents are very uncommon.

References

Jan 1, 1986·The American Journal of Cardiology
Oct 1, 1989·Cardiovascular Drugs and Therapy·M J AntonaccioJ E Byrne
Mar 1, 1988·The American Journal of Cardiology·UNKNOWN Cardiac Arrhythmia Pilot Study (CAPS) Investigators
Apr 1, 1989·The American Journal of Cardiology·B N Singh
Jun 1, 1970·British Journal of Pharmacology·J P Finberg, W S Peart
Aug 1, 1970·British Journal of Pharmacology·B N Singh, E M Vaughan Williams

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Citations

Jan 2, 1990·The American Journal of Cardiology·B N Singh
Feb 23, 2000·Journal of Cardiovascular Pharmacology and Therapeutics·M Valderrábano, B N Singh

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