PMID: 9425341DOI: 10.1016/s0955-0674(97)80077-4Jan 13, 1998Paper
Controlling cell proliferation in differentiating tissues: genetic analysis of negative regulators of G1-->S-phase progression
Current Opinion in Cell Biology
K H Zavitz, S L Zipursky
Abstract
Withdrawal from the cell cycle as cells begin to differentiate is accomplished by the downregulation of cyclin-dependent kinase activities in G1 phase. Recent analysis of loss-of-function mutations in flies, worms, and mice has provided insight into the roles of various negative regulators of G1 phase in developing organisms.
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