Controlling cell proliferation in differentiating tissues: genetic analysis of negative regulators of G1-->S-phase progression

Current Opinion in Cell Biology
K H Zavitz, S L Zipursky

Abstract

Withdrawal from the cell cycle as cells begin to differentiate is accomplished by the downregulation of cyclin-dependent kinase activities in G1 phase. Recent analysis of loss-of-function mutations in flies, worms, and mice has provided insight into the roles of various negative regulators of G1 phase in developing organisms.

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