Controlling Complexity of Cerebral Cortex Simulations-I: CxSystem, a Flexible Cortical Simulation Framework
Abstract
Simulation of the cerebral cortex requires a combination of extensive domain-specific knowledge and efficient software. However, when the complexity of the biological system is combined with that of the software, the likelihood of coding errors increases, which slows model adjustments. Moreover, few life scientists are familiar with software engineering and would benefit from simplicity in form of a high-level abstraction of the biological model. Our primary aim was to build a scalable cortical simulation framework for personal computers. We isolated an adjustable part of the domain-specific knowledge from the software. Next, we designed a framework that reads the model parameters from comma-separated value files and creates the necessary code for Brian2 model simulation. This separation allows rapid exploration of complex cortical circuits while decreasing the likelihood of coding errors and automatically using efficient hardware devices. Next, we tested the system on a simplified version of the neocortical microcircuit proposed by Markram and colleagues ( 2015 ). Our results indicate that the framework can efficiently perform simulations using Python, C <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mrow><mml:m...Continue Reading
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