Controlling infectious disease through the targeted manipulation of contact network structure

Epidemics
M Gates, M E J Woolhouse

Abstract

Individuals in human and animal populations are linked through dynamic contact networks with characteristic structural features that drive the epidemiology of directly transmissible infectious diseases. Using animal movement data from the British cattle industry as an example, this analysis explores whether disease dynamics can be altered by placing targeted restrictions on contact formation to reconfigure network topology. This was accomplished using a simple network generation algorithm that combined configuration wiring with stochastic block modelling techniques to preserve the weighted in- and out-degree of individual nodes (farms) as well as key demographic characteristics of the individual network connections (movement date, livestock market, and animal production type). We then tested a control strategy based on introducing additional constraints into the network generation algorithm to prevent farms with a high in-degree from selling cattle to farms with a high out-degree as these particular network connections are predicted to have a disproportionately strong role in spreading disease. Results from simple dynamic disease simulation models predicted significantly lower endemic disease prevalences on the trade restricted...Continue Reading

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Citations

Mar 18, 2016·Journal of the Royal Society, Interface·Mathieu Moslonka-LefebvreElisabeta Vergu
Oct 11, 2016·Preventive Veterinary Medicine·Arata HidanoM Carolyn Gates
Mar 21, 2017·Frontiers in Veterinary Science·Anne RelunBeatriz Martínez-López
Jul 27, 2017·PLoS Computational Biology·Christopher Finn McQuaidChristopher Aidan Gilligan
Apr 7, 2018·PLoS Computational Biology·Stefan SellmanTom Lindström
Nov 18, 2017·PLoS Neglected Tropical Diseases·Raquel Martins LanaCláudia Torres Codeço
Jan 7, 2020·Transboundary and Emerging Diseases·Y LiI D Robertson
Sep 17, 2020·Veterinary Medicine and Science·Helen R FieldingRobbie A McDonald
Mar 28, 2020·New Zealand Veterinary Journal·S S GreeningM C Gates
Sep 29, 2020·Transboundary and Emerging Diseases·Mary van AndelM Carolyn Gates
Jan 7, 2021·PloS One·Frederik SchirdewahnBeatriz Vidondo
Feb 3, 2021·Transboundary and Emerging Diseases·Dennis N MakauKimberly VanderWaal
May 8, 2021·Royal Society Open Science·Peter BrommessonTom Lindström
Aug 16, 2017·Microbiology Spectrum·Mark Woolhouse
Oct 26, 2021·Transboundary and Emerging Diseases·Hao TangMieghan Bruce

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