Controlling invasive pneumococcal disease: is vaccination of at-risk groups sufficient?

International Journal of Clinical Practice
M A FletcherF J Malinoski

Abstract

Risk factors for invasive pneumococcal disease (IPD) include young and old age, comorbidities (such as splenic dysfunction, immunodeficiencies, chronic renal disease, chronic heart or lung disease or cerebral spinal fluid leak), crowded environments or poor socioeconomic conditions. Universal use of the 7-valent pneumococcal conjugate (7vPncCRM) vaccine for infants and young children has led to significant decreases in IPD in the vaccinated population (direct protection), and there has also been a decrease in the incidence of IPD among the nonvaccinated population (indirect immunity; herd protection). While 7vPncCRM vaccine is administered universally to children in USA, many countries of the European Union have chosen to target children with comorbidities. This review aims to highlight individual risk factors for IPD, describe studies that evaluated pneumococcal conjugate vaccines in at-risk groups and estimate the proportion of at-risk children who may have been vaccinated in the European Union since the 7vPncCRM vaccine was introduced, using UK as an example. Although immunisation targeting only children with comorbidities may achieve satisfactory results for a few, many otherwise healthy children at risk simply because of t...Continue Reading

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Citations

Sep 9, 2006·Epidemiology and Infection·E D G McIntoshM A Fletcher
Nov 1, 2006·International Journal of Clinical Practice·P J Rees
Oct 22, 2009·The British Journal of General Practice : the Journal of the Royal College of General Practitioners·Yana VinogradovaCarol Coupland
Apr 23, 2010·International Journal of Antimicrobial Agents·M HoeniglA J Grisold
Nov 4, 2008·International Journal of Antimicrobial Agents·Atef ShiblStephen Pelton
Aug 25, 2009·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Daniel J IsaacmanRalf R Reinert
Oct 3, 2017·Biomédica : revista del Instituto Nacional de Salud·Paola Andrea PalaciosJaime Moreno
Dec 7, 2013·Expert Review of Respiratory Medicine·Kerry-Ann F O'GradyKeith Grimwood
Dec 5, 2008·Expert Review of Vaccines·Guilherme Gonçalves

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BETA
cochlear implant

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