Controlling Mast Cell Activation and Homeostasis: Work Influenced by Bill Paul That Continues Today

Frontiers in Immunology
Heather L CaslinJohn J Ryan

Abstract

Mast cells are tissue resident, innate immune cells with heterogenous phenotypes tuned by cytokines and other microenvironmental stimuli. Playing a protective role in parasitic, bacterial, and viral infections, mast cells are also known for their role in the pathogenesis of allergy, asthma, and autoimmune diseases. Here, we review factors controlling mast cell activation, with a focus on receptor signaling and potential therapies for allergic disease. Specifically, we will discuss our work with FcεRI and FγR signaling, IL-4, IL-10, and TGF-β1 treatment, and Stat5. We conclude with potential therapeutics for allergic disease. Much of these efforts have been influenced by the work of Bill Paul. With many mechanistic targets for mast cell activation and different classes of therapeutics being studied, there is reason to be hopeful for continued clinical progress in this area.

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Citations

Dec 7, 2018·Clinical Reviews in Allergy & Immunology·Daniel Elieh Ali Komi, Leif Bjermer
May 31, 2019·International Journal of Molecular Sciences·Chan-Hee YuOk-Nam Bae
Oct 3, 2020·Tissue Engineering. Part a·Emily W OzpinarDonald O Freytes
Jul 6, 2018·Frontiers in Immunology·Hua HuangFred D Finkelman
Mar 19, 2019·Expert Review of Clinical Immunology·Theoharis C TheoharidesHuali Ren
Oct 7, 2020·Brain Sciences·Agnieszka J SzczepekAlina Smorodchenko
Oct 18, 2020·Molecular and Cellular Neurosciences·Jack Reddaway, Nichola M Brydges
Jan 24, 2021·Experimental Hematology·Norman F RusskampMarkus G Manz
Jan 1, 2021·Research in Veterinary Science·James C TarrantEnrico Radaelli
Jan 30, 2021·Journal of Digestive Diseases·Li ChengSheng Liang Chen
Apr 2, 2021·Frontiers in Immunology·Maud A W HermansWillem A Dik
May 12, 2020·Current Protein & Peptide Science·Huda Fatima RajaniMohammad Mahmoudi Gomari
Jul 9, 2021·Frontiers in Microbiology·Dominika Jakubczyk, Sabina Górska
Aug 3, 2021·Frontiers in Cellular and Infection Microbiology·Amanda Gubert Alves Dos SantosGessilda de Alcantara Nogueira-Melo

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Methods Mentioned

BETA
PMA

Clinical Trials Mentioned

NCT02918019
NCT02920021

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