PMID: 11902927Mar 21, 2002Paper

Controlling molecular weight and degree of deacetylation of chitosan by response surface methodology

Journal of Agricultural and Food Chemistry
Kwon T HwangHyun J Park

Abstract

Response surface methodology (RSM) was used for controlling molecular weight (MW) and degree of deacetylation (DOD) of chitosan in chemical processing. In a reduced model, MW of chitosan is y = 1736166.406 - 250.745X(1)X(2) - 265.452X(2)X(3), with R( 2) = 0.86, and DOD of chitosan is y = 30.6069 + 0.3396X(1) + 0.4948X(2) + 0.0094X(3)(2), with R( 2) = 0.89. MW of chitosan depends on the crossproduct of temperature and NaOH concentration and the crossproduct of NaOH concentration and time, and DOD depends linearly on temperature and NaOH concentration, and quadratically on time. Chitosan was widely depolymerized in a range from 1,100 kDa to 100 kDa and deacetylated from 67.3 to 95.7% by NaOH alkaline treatment. MW and DOD of chitosan were drastically decreased and increased, respectively, with increase of temperature, reaction time, and NaOH concentration. Furthermore, the rate of MW decrease and DOD increase of chitosan gradually decreased with prolonged reaction time.

Citations

Mar 27, 2015·Marine Drugs·Adnan A BadwanFouad H Darras
Nov 6, 2012·Carbohydrate Polymers·A P Martínez-CamachoM Plascencia-Jatomea
Nov 15, 2006·Pharmaceutical Development and Technology·Bijay Kumar PadhiAmbikanandan Misra
Apr 13, 2011·Physical Chemistry Chemical Physics : PCCP·Katharine W MooreHerschel Rabitz
Sep 30, 2008·Pharmaceutical Development and Technology·Udhumansha UbaidullaPurnima Tripathi
Aug 22, 2003·Journal of Food Protection·Kyung W KimHyun J Park
Dec 7, 2020·International Journal of Biological Macromolecules·Shijie Gabriel KouMichael R Mucalo
Dec 29, 2020·Carbohydrate Polymers·Juliana Rodrigues de Souza, Reinaldo Giudici
May 22, 2021·Nanoscale Horizons : the Home for Rapid Reports of Exceptional Significance in Nanoscience and Nanotechnolgy·Tony JinAudrey Moores

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