Controlling NO Production Upon Valence Ionization of Nitroimidazoles

The Journal of Physical Chemistry. a
Eero ItäläEdwin Kukk

Abstract

Nitroimidazole exhibits a remarkable regioselective fragmentation subsequent to valence ionization, which is characterized by ejection of NO. As NO is also considered to be an effective radiosensitizer, we investigated its production efficiency as a function of isomeric composition (the site of the NO2 nitro group). We observe strong dependence in the 8.6-15 eV binding energy range, and moreover, that the production of NO can be effectively suppressed by methylation of nitroimidazole. This behavior can be understood by modification of the valence electronic structure with respect to the dissociation threshold, which gives rise to varying effective density of dissociative states. We find the NO yield to follow the efficiency of the nitroimidazole dervivatives as radiosensitizers, found in preclinical studies.

References

Apr 1, 2008·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Rumi MurataMichael R Horsman
Apr 13, 2012·Translational Oncology·Bryan T OronskyJan J Scicinski
Jun 24, 2014·The Journal of Chemical Physics·E ItäläE Kukk
Apr 23, 2015·Physical Chemistry Chemical Physics : PCCP·Linda FeketeováRichard A J O'Hair
Sep 8, 2015·The Journal of Physical Chemistry. a·Linda FeketeováKevin C Prince
Nov 24, 2016·The Journal of Chemical Physics·P BolognesiL Avaldi
Mar 3, 2017·Physical Chemistry Chemical Physics : PCCP·Tomas Baer, Richard P Tuckett
Aug 2, 2017·Journal of Mass Spectrometry : JMS·Eero ItäläEdwin Kukk

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Citations

Nov 2, 2019·Journal of the American Society for Mass Spectrometry·Rebecca MeißnerStephan Denifl
Jun 10, 2020·The Journal of Physical Chemistry. a·Eero ItäläEdwin Kukk
Oct 2, 2021·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Mauro SattaPaola Bolognesi

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