Controlling nuclear RNA levels.

Nature Reviews. Genetics
Manfred Schmid, Torben Heick Jensen

Abstract

RNA turnover is an integral part of cellular RNA homeostasis and gene expression regulation. Whereas the cytoplasmic control of protein-coding mRNA is often the focus of study, we discuss here the less appreciated role of nuclear RNA decay systems in controlling RNA polymerase II (RNAPII)-derived transcripts. Historically, nuclear RNA degradation was found to be essential for the functionalization of transcripts through their proper maturation. Later, it was discovered to also be an important caretaker of nuclear hygiene by removing aberrant and unwanted transcripts. Recent years have now seen a set of new protein complexes handling a variety of new substrates, revealing functions beyond RNA processing and the decay of non-functional transcripts. This includes an active contribution of nuclear RNA metabolism to the overall cellular control of RNA levels, with mechanistic implications during cellular transitions.

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Sep 14, 2018·Nucleic Acids Research·Marta Lloret-LlinaresTorben Heick Jensen
May 29, 2019·ELife·Salma Sohrabi-JahromiPatrick Cramer
Jun 24, 2018·The EMBO Journal·Mathias Munschauer, Jörg Vogel
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Jun 4, 2019·Journal of Molecular Cell Biology·Michaela Müller-McNicollJan Medenbach
Jan 18, 2020·Nucleic Acids Research·Toomas SillaTorben Heick Jensen
May 29, 2020·Nucleic Acids Research·Mireille MelkoTorben Heick Jensen
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Jul 28, 2020·Nucleic Acids Research·Mengjun WuAlbin Sandelin
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May 4, 2021·Wiley Interdisciplinary Reviews. RNA·Pierre BensidounMarlene Oeffinger
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