Controlling Particle Size and Release Kinetics in the Sustained Delivery of Oral Antibiotics Using pH-Independent Mucoadhesive Polymers.

Molecular Pharmaceutics
Cristina YusManuel Arruebo

Abstract

Copolymers synthesized from acrylic acid and methacrylic acid used as gastroprotective and mucoadhesive enteric coatings have been used to prepare micro- (∼2 μm), submicro- (∼200 nm), and nanoparticles (∼20 nm) containing rifampicin (Rif) to obtain time-controlled drug release kinetics. Different particle sizes and drug release kinetics have been obtained using different synthesis conditions and fabrication techniques including the use of an electrosprayer and an interdigital microfabricated micromixer. The antimicrobial action of the encapsulated Rif has been demonstrated against Staphylococcus aureus ATCC 25923 and compared with the effect of the equivalent dose of the free macrolide antibiotic. At low concentrations, the encapsulated antibiotic showed superior antimicrobial activity than the free drug. The stability of the developed particles has been evaluated in vitro under simulated gastric and intestinal conditions. At the concentrations tested, a reduced cytotoxicity against different human cell lines was observed after analyzing their subcytotoxic doses and the influence on their cell cycle by flow cytometry. Drug release kinetics can be tuned by adjusting particle sizes, and it would be possible to reach the minimum i...Continue Reading

References

Feb 1, 1983·The Journal of Infectious Diseases·C W Norden, M Shaffer
Apr 9, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·C AtumaL Holm
Aug 7, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·A F Widmer
Sep 20, 2001·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·S IsefukuA H Simpson
May 26, 2004·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Shrutidevi AgrawalRamesh Panchagnula
Jun 29, 2006·Current Opinion in Infectious Diseases·Andrej Trampuz, Andreas F Widmer
Jul 22, 2008·International Journal of Pharmaceutics·Praveen S Hiremath, Ranendra N Saha
Nov 22, 2008·Archives of Pharmacal Research·N DuránP D Marcato
Feb 19, 2009·Antimicrobial Agents and Chemotherapy·Anne SandbergNiels Frimodt-Møller
Oct 13, 2009·International Journal of Pharmaceutics·Gaurav Kant SaraogiG P Agrawal
Oct 13, 2010·Annual Review of Physiology·Le ShenJerrold R Turner
Apr 5, 2011·International Journal of Pharmaceutics·Juergen Siepmann, Nicholas A Peppas
Apr 14, 2011·Pharmaceutical Development and Technology·D P MauryaA Ali
Sep 24, 2014·International Journal of Nanomedicine·Wenji ZhangJun Kong
Dec 31, 2015·PloS One·Natalya PanovaDominik Rejman
Aug 16, 2016·International Journal of Nanomedicine·Isabel Ortiz de SolorzanoManuel Arruebo
Oct 28, 2016·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Laura C Luciani-GiacobbeMaría E Olivera
Sep 6, 2017·The Journal of Infection·Chun-Yuan LeePo-Ren Hsueh
Dec 28, 2017·Carbohydrate Polymers·Christopher J WinslowAndrew P Neilson
Mar 28, 2018·Proceedings of the National Academy of Sciences of the United States of America·Eili Y KleinRamanan Laxminarayan
Jun 30, 2018·Nature Biomedical Engineering·Sazid HussainErkki Ruoslahti
Jul 27, 2018·International Journal of Biological Macromolecules·Ruben GraciaManuel Arruebo
Dec 21, 2018·Journal of Controlled Release : Official Journal of the Controlled Release Society·Paul LuethBryan H Bellaire
Oct 17, 2019·Polymers·Cristina YusManuel Arruebo

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Citations

Oct 30, 2020·Drug Design, Development and Therapy·Nasrul WathoniMuchtaridi Muchtaridi

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