Controlling seizure propagation in large-scale brain networks

PLoS Computational Biology
Simona OlmiViktor K Jirsa

Abstract

Information transmission in the human brain is a fundamentally dynamic network process. In partial epilepsy, this process is perturbed and highly synchronous seizures originate in a local network, the so-called epileptogenic zone (EZ), before recruiting other close or distant brain regions. We studied patient-specific brain network models of 15 drug-resistant epilepsy patients with implanted stereotactic electroencephalography (SEEG) electrodes. Each personalized brain model was derived from structural data of magnetic resonance imaging (MRI) and diffusion tensor weighted imaging (DTI), comprising 88 nodes equipped with region specific neural mass models capable of demonstrating a range of epileptiform discharges. Each patient's virtual brain was further personalized through the integration of the clinically hypothesized EZ. Subsequent simulations and connectivity modulations were performed and uncovered a finite repertoire of seizure propagation patterns. Across patients, we found that (i) patient-specific network connectivity is predictive for the subsequent seizure propagation pattern; (ii) seizure propagation is characterized by a systematic sequence of brain states; (iii) propagation can be controlled by an optimal interve...Continue Reading

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Citations

Sep 29, 2020·Journal of Epilepsy Research·Sora AnHyang Woon Lee
Oct 8, 2020·Brain Sciences·Niels Alexander FoitNeda Ladbon-Bernasconi
Jan 26, 2021·PLoS Computational Biology·Vinícius Rezende CarvalhoEduardo Mazoni Andrade Marçal Mendes
Mar 21, 2020·NeuroImage·Hannelore AertsDaniele Marinazzo
Jun 2, 2020·Neurosurgery Clinics of North America·Niels Alexander FoitNeda Bernasconi
Mar 30, 2021·Brain Topography·Katharina GlombBenedetta Franceschiello
Apr 10, 2020·Seizure : the Journal of the British Epilepsy Association·Hitten P ZaveriKlaus Lehnertz
May 4, 2021·Frontiers in Computational Neuroscience·Hae-Jeong Park, Jiyoung Kang
Jun 1, 2021·Frontiers in Neurology·William J BoslTobias Loddenkemper
Jul 6, 2021·Seizure : the Journal of the British Epilepsy Association·Damien DepannemaeckerChristophe Bernard
Jul 12, 2021·Epilepsia·Aileen McGonigalPatrick Chauvel

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Methods Mentioned

BETA
surgical resection

Software Mentioned

SCRIPTS
FSL
MRtrix3
FreeSurfer
Remesher

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