Controlling the Balance of Fibroblast Proliferation and Differentiation: Impact of Thy-1

The Journal of Investigative Dermatology
Manuela SchmidtAnja Saalbach

Abstract

Fibroblasts provide matrix and regulatory mediators to the microenvironment and thereby contribute to maintenance of tissue homeostasis, wound healing, and tumor progression. In the present study, we addressed the functional relevance of Thy-1 for fibroblast functions in vitro and in vivo. Using fibroblasts from Thy-1(-/-) and wild-type mice, recombinant expression of Thy-1, and analysis of the interaction of fibroblasts with immobilized Thy-1, we showed that Thy-1 has a crucial role in the control of cell growth by suppressing proliferation and promoting apoptosis and differentiation of dermal fibroblasts. Function-blocking studies revealed that Thy-1 mediates the control of apoptosis and proliferation via modulation of β3 integrin function. Interestingly, Thy-1-mediated growth control appears to be a more general mechanism because it also regulates growth of tumor cells of different origin dependent on their β3 integrin expression. In summary, our findings point to an important role of Thy-1 in controlling the balance between proliferation and differentiation in dermal fibroblasts.

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Citations

Mar 12, 2016·The Journal of Investigative Dermatology·Manuela SchmidtAnja Saalbach
Oct 16, 2018·The American Journal of Dermatopathology·Jonathan Dale HoJag Bhawan
May 28, 2019·Endocrine Reviews·Zachary L SeboMark C Horowitz
Feb 28, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Anja Saalbach, Ulf Anderegg
Dec 11, 2019·Lasers in Surgery and Medicine·Dimakatso R MokoenaHeidi Abrahamse
Aug 11, 2019·Nature Communications·Huimei ChenEnrico Petretto
Aug 21, 2019·Frontiers in Cell and Developmental Biology·Lisette LeytonRamón D Pérez
Mar 15, 2020·Stem Cell Reviews and Reports·Mahmut ParmaksizYaşar Murat Elçin
Apr 21, 2017·Science Translational Medicine·Nadine LohmannUwe Freudenberg
Oct 20, 2018·Frontiers in Cell and Developmental Biology·Ann-Kristin PickeAnja Saalbach
Nov 3, 2020·MethodsX·Melissa BlumDevavani Chatterjea
Dec 3, 2020·Journal of Clinical Medicine·Christina B BrazelAnja Saalbach
May 3, 2021·Journal of Cellular Physiology·Aleksandra JaukovićDiana Bugarski
Aug 10, 2018·Science Translational Medicine·Ann-Kristin PickeAnja Saalbach

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