PMID: 11341989May 9, 2001Paper

Controlling the efficiency of excision repair

Mutation Research
P C Hanawalt

Abstract

The early studies are recounted, that led to the discovery of the ubiquitous process of DNA excision repair, followed by a review of the pathways of transcription-coupled repair (TCR) and global genomic nucleotide excision repair (GGR). Repair replication of damaged DNA in UV-irradiated bacteria was discovered through the use of 5-bromouracil to density-label newly synthesized DNA. This assay was then used in human cells to validate the phenomenon of unscheduled DNA synthesis as a measure of excision repair and to elucidate the first example of a DNA repair disorder, xeroderma pigmentosum. Features of the TCR pathway (that is defective in Cockayne syndrome (CS)) include the possibility of "gratuitous TCR" at transcription pause sites in undamaged DNA. The GGR pathway is shown to be controlled through the SOS stress response in E. coli and through the activated product of the p53 tumor suppressor gene in human cells. These regulatory systems particularly affect the efficiency of repair of the predominant UV-induced photoproduct, the cyclobutane pyrimidine dimer, as well as that of chemical carcinogen adducts, such as benzo(a)pyrene diol-epoxide. Rodent cells (typically lacking the p53-controlled GGR pathway) and tumor virus infe...Continue Reading

References

Oct 15, 1975·Journal of Molecular Biology·A R GrivellP C Hanawalt
Jan 1, 1975·Basic Life Sciences·D BootsmaW Keÿzez
Nov 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·K S Sweder, P C Hanawalt
Nov 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·S Kunala, D E Brash
May 11, 1991·Nucleic Acids Research·H VrielingA A van Zeeland
Jun 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·J VenemaL V Mayne
Dec 1, 1988·Molecular and Cellular Biology·S A Leadon, M M Snowden
Aug 22, 1973·Nature: New Biology·W MaskerH Shizuya
Jan 1, 1968·Cold Spring Harbor Symposia on Quantitative Biology·P C HanawaltJ L Couch
Dec 1, 1965·Proceedings of the National Academy of Sciences of the United States of America·C Pauling, P Hanawalt
Nov 11, 1980·Nucleic Acids Research·R S LloydM L Dodson
Sep 12, 1995·Proceedings of the National Academy of Sciences of the United States of America·J M Ford, P C Hanawalt
Dec 23, 1994·Science·P C Hanawalt
Mar 3, 1995·The Journal of Biological Chemistry·C P Selby, A Sancar
Aug 30, 1994·Proceedings of the National Academy of Sciences of the United States of America·B A DonahueP C Hanawalt
Nov 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·S A Leadon, P K Cooper
Oct 5, 1993·Biochemistry·F C Christians, P C Hanawalt
Apr 2, 1993·Science·C P Selby, A Sancar
Feb 6, 1996·Proceedings of the National Academy of Sciences of the United States of America·I Mellon, G N Champe
Jan 1, 1996·Annual Review of Biochemistry·E C Friedberg
Jan 1, 1996·Annual Review of Biochemistry·A Sancar
Jan 1, 1997·Molecular and Cellular Biology·R Dammann, G P Pfeifer
Apr 15, 1997·Proceedings of the National Academy of Sciences of the United States of America·J CourcelleP C Hanawalt
Feb 11, 1998·The Journal of Investigative Dermatology·A NakagawaT Mori

❮ Previous
Next ❯

Citations

Jun 1, 2005·Biochimica Et Biophysica Acta·Leena Latonen, Marikki Laiho
Jul 18, 2003·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Rafael RosellEnriqueta Felip
Nov 6, 2003·Toxicology·Markus ChristmannBernd Kaina
Jan 2, 2003·DNA Repair·Gijsbertus T J van der HorstErrol C Friedberg
Jun 24, 2010·Nature Reviews. Molecular Cell Biology·Caterina Strambio-De-CastilliaMichael P Rout
Oct 17, 2006·Nature Reviews. Microbiology·Josephine Kang, Martin J Blaser
Jan 22, 2004·The Journal of Biological Chemistry·Shisheng Li, Michael J Smerdon
Jul 19, 2003·Human Gene Therapy·Catherine Arnaudeau-BégardThierry Magnaldo
Sep 25, 2004·Nucleic Acids Research·Marie TouchonClaude Thermes
Jun 1, 2007·Nucleic Acids Research·Hélène GaillardAndrés Aguilera
Nov 24, 2011·Pharmacogenetics and Genomics·Hongxia MaQingyi Wei
Jul 30, 2004·Molecular and Cellular Biology·Christoph CapiaghiFritz Thoma
Mar 10, 2007·Microbiology and Molecular Biology Reviews : MMBR·Ekaterina V Mirkin, Sergei M Mirkin
Feb 16, 2005·Annual Review of Physiology·Dietmar Kültz
Jan 1, 2002·The Arabidopsis Book·Anne Britt
Jan 10, 2002·Proceedings of the National Academy of Sciences of the United States of America·Antonio ConconiMichael J Smerdon
Apr 8, 2014·Molecular Biology International·Bernadette ConnorsGraham Howard
Jan 29, 2016·Journal of Cellular and Molecular Medicine·Yun-Zhi ChenMeng-Tao Zhou
Jan 24, 2007·American Journal of Surgery·Maximo A BenavidesWilliam E Grizzle
May 12, 2010·Journal of Cellular Physiology·Liren LiuPengbo Zhou
Mar 29, 2016·Journal of Cellular and Molecular Medicine·Jing HeHuimin Xia
Feb 26, 2004·Seminars in Oncology·Rafael RosellRosario García-Campelo
Jun 6, 2012·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·D T AriozM Yilmazer
Oct 16, 2009·The Journal of Investigative Dermatology·Coimbatore S SreevidyaStephen E Ullrich

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.