Controlling the Spatial Distribution of Solubilized Compounds within Copolymer Micelles

Langmuir : the ACS Journal of Surfaces and Colloids
Alessandro IaniroRemco Tuinier

Abstract

The solubilization of lyophobic compounds in block copolymer micelles has been extensively investigated but remains only partially understood. There is a need to understand the fundamental parameters that determine the spatial distribution of the solubilized compounds within the micelles. Controlling this feature is a key aspect in the design of drug delivery systems with tailored release properties. Using Scheutjens-Fleer self-consistent field (SF-SCF) computations, we found that solubilization is regulated by a complex interplay between enthalpic and entropic contributions and that the spatial distribution can be controlled by the concentration and solubility of the guest compound in the dispersion medium. Upon solubilization, a characteristic change in size and mass of the micelles is predicted. This can be used as a fingerprint to indirectly assess the spatial distribution. Based on these findings, we developed two experimental protocols to control and assess the spatial distribution of lyophobic compounds within block copolymer micelles.

References

Sep 25, 2003·Journal of the American Chemical Society·Amira Choucair, Adi Eisenberg
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Jul 8, 2008·International Journal of Pharmaceutics·Mickael ChaussonIsabelle Bonnet
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Citations

Jun 25, 2019·Therapeutic Delivery·Catarina P Reis
Jan 18, 2020·Soft Matter·Álvaro González GarcíaRemco Tuinier
Mar 9, 2021·Soft Matter·Pietro CorsiBarbara Capone
Jul 18, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·Christine M PapadakisAndré Laschewsky
Dec 18, 2021·Proceedings of the National Academy of Sciences of the United States of America·Fleurie M KelleyBenjamin S Schuster

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Methods Mentioned

BETA
X-ray
static light-scattering
light scattering
Light-Scattering
electron microscopy

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