Controlling the structure and photophysics of fluorophore dimers using multiple cucurbit[8]uril clampings.

Chemical Science
Guanglu WuOren A Scherman

Abstract

A modular strategy has been employed to develop a new class of fluorescent molecules, which generates discrete, dimeric stacked fluorophores upon complexation with multiple cucurbit[8]uril macrocycles. The multiple constraints result in a "static" complex (remaining as a single entity for more than 30 ms) and facilitate fluorophore coupling in the ground state, showing a significant bathochromic shift in absorption and emission. This modular design is surprisingly applicable and flexible and has been validated through an investigation of nine different fluorophore cores ranging in size, shape, and geometric variation of their clamping modules. All fluorescent dimers evaluated can be photo-excited to atypical excimer-like states with elongated excited lifetimes (up to 37 ns) and substantially high quantum yields (up to 1). This strategy offers a straightforward preparation of discrete fluorophore dimers, providing promising model systems with explicitly stable dimeric structures and tunable photophysical features, which can be utilized to study various intermolecular processes.

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Citations

Jun 5, 2020·Angewandte Chemie·Guanglu WuOren A Scherman
Nov 19, 2020·Chemistry : a European Journal·Steven MurkliLyle Isaacs
Jun 10, 2021·Physical Chemistry Chemical Physics : PCCP·Heather F HigginbothamToby D M Bell
Aug 6, 2021·Chemical Science·Héctor Barbero, Eric Masson
Sep 5, 2020·Journal of the American Chemical Society·Huang WuJ Fraser Stoddart
Jun 24, 2021·Chemistry, an Asian Journal·Shubhra Kanti BhaumikSupratim Banerjee
Aug 20, 2021·Journal of the American Chemical Society·Hua-Jiang YuYu Liu

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Methods Mentioned

BETA
NMR
chemical exchange
nuclear magnetic resonance

Software Mentioned

Ph135Me
fsTA

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