PMID: 11910582Mar 26, 2002Paper

Controversial issues in climacteric medicine I. Cardiovascular disease and hormone replacement therapy. International Menopause Society Expert Workshop. 13-16 October 2000, royal society of medicine, London, UK

Climacteric : the Journal of the International Menopause Society
A R GenazzaniInternational Menopause Society

Abstract

The clinical benefits of HRT are clearly established for the relief of menopausal symptoms, improving quality of life and the prevention of osteoporosis. Although research on the impact of HRT (oral, transdermal, tibolone, etc.) and on the effects of raloxifene on CVD is still ongoing, with certain unresolved controversies, studies using a variety of different HRT formulations have shown a clear benefit on surrogate markers of CHD and epidemiological and clinical, although not randomized, studies have demonstrated a CHD reduction in HRT-treated women. Today, HRT may be used for the primary prevention of CVD. Conversely, there is no clear reason to commence HRT solely or primarily to confer an immediate cardiovascular benefit in postmenopausal women with established CHD. Equally, there is no compelling evidence for discontinuing--or indeed not initiating--HRT in women without CVD because of concern about cardiovascular risk. In any case, all medical interventions should be individualized to the specific woman's age, characteristics and needs. The ultimate effects of different dosages, schedules and type of hormones used should be clarified, avoiding inferring the effects of one form of HRT to others. The importance of increased ...Continue Reading

References

Jan 1, 1990·Annals of the New York Academy of Sciences·M J StampferW C Willett
Jan 1, 1990·Annals of the New York Academy of Sciences·T L Bush
Mar 1, 1988·Annals of Internal Medicine·J M SullivanD M Mirvis
May 1, 1988·American Heart Journal·H W GruchowK A Sobocinski
Apr 30, 1987·The New England Journal of Medicine·G A ColditzC H Hennekens
Mar 1, 1973·Endocrinology·M L Matute, R K Kalkhoff
Jan 1, 1981·American Journal of Obstetrics and Gynecology·L RosenbergF E Speizer
May 15, 1993·Lancet·P CollinsP A Poole-Wilson
Aug 1, 1996·European Heart Journal·K Schenck-Gustafsson
Feb 1, 1997·The Journal of Clinical Endocrinology and Metabolism·M GambaccianiA R Genazzani
May 26, 1998·JAMA : the Journal of the American Medical Association·B W WalshP W Anderson
Nov 20, 1998·Maturitas·F Grodstein, M J Stampfer
Feb 4, 1999·Journal of Women's Health·J C Lovejoy
Mar 26, 1999·Maturitas·E Barrett-ConnorP W Anderson
May 21, 1999·Archives of Internal Medicine·F B HuM J Stampfer
Jun 11, 1999·The New England Journal of Medicine·M E Mendelsohn, R H Karas
Sep 22, 1999·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·K RäikkönenL H Kuller
Jan 26, 2000·Menopause : the Journal of the North American Menopause Society·B SzekacsE A Brinton
Mar 25, 2000·American Journal of Epidemiology·K A DoL Dennerstein
Jun 16, 2000·Molecular and Cellular Endocrinology·T Simoncini, A R Genazzani
Jul 7, 2000·The New England Journal of Medicine·S C GanL Chan
Jul 7, 2000·The New England Journal of Medicine·M J StampferW C Willett
Aug 18, 2000·The Journal of Clinical Endocrinology and Metabolism·T Simoncini, A R Genazzani
Aug 24, 2000·The New England Journal of Medicine·D M HerringtonD Waters
Aug 24, 2000·The New England Journal of Medicine·F B HuW C Willett

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Citations

Jan 25, 2003·Menopause : the Journal of the North American Menopause Society·Gail B MahadyAlice Dan
Jan 16, 2008·Menopause : the Journal of the North American Menopause Society·Tommaso SimomciniAndrea R Genazzani
Feb 1, 2003·Nutrition in Clinical Care : an Official Publication of Tufts University·Gail B MahadyBirgit Dietz
Oct 27, 2001·Circulation Research·M J EvansD C Harnish
Jan 8, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mikhail KorokinMikhail Pokrovskii
Jan 5, 2006·Climacteric : the Journal of the International Menopause Society·J C StevensonM Gelfand
Jul 10, 2009·Current Opinion in Oncology·Rachel Michaelson-Cohen, Uziel Beller
May 14, 2011·Archives of Gerontology and Geriatrics·Valéria BonganhaRoberto Vilarta

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